在心室重塑中存在争议
Lionel H Opie1, Patrick J Commerford, Bernard J Gersh
1Hatter Institute for Heart Research, Cape Heart Centre and Department of Medicine, University of Cape Town Faculty of Health Sciences, Observatory 7925, Cape Town, South Africa. Opie@capeheart.uct.ac.za
Lancet (London, England)
|January 31, 2006
概括
心室重塑涉及到心脏的结构变化.
科学领域:
- 心血管生物学和病理学.
- 心脏重塑机制. 心脏重塑机制.
- 心力衰竭的病理生理学.
背景情况:
- 心室重塑包括由于负载条件的慢性变化而导致左心室的结构变化.
- 关键的模式包括同心重塑 (压力负荷),古怪的缩 (体积负荷) 和心肌梗塞.
- 左心室缩的适应性与不适应性的性质仍在争论中,有大动脉狭窄和信号通路的影响.
研究的目的:
- 审查心室重塑和过渡到心力衰竭的病理生理学.
- 讨论针对这些复杂过程的新兴和新的治疗策略.
主要方法:
- 审查关于心室重塑,缩和心力衰竭的现有文献.
- 基于机械学的见解,讨论潜在的治疗干预措施.
主要成果:
- 过渡到心力衰竭涉及金属蛋白酶,反应性氧物种和神经幽默因子的复杂相互作用.
- 提出了几种新的治疗途径,包括药理学药物,手术干预和基于细胞的疗法.
结论:
- 心室重塑是一个动态的过程,对心力衰竭的发展具有关键意义.
- 针对特定分子通路和机械干预的新型治疗策略为治疗心力衰竭提供了潜在的潜力.
相关概念视频
Anatomy of the Heart
The human heart is made up of three layers of tissue that are surrounded by the pericardium, a membrane that protects and confines the heart. The outermost layer, closest to the pericardium, is the epicardium. The pericardial cavity separates the pericardium from the epicardium. Beneath the epicardium is the myocardium, the middle layer, and the endocardium, the innermost layer. There are four chambers of the heart: the right atrium, the right ventricle, the left atrium, and the left ventricle.
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The heart wall comprises three distinct layers: the epicardium, myocardium, and endocardium. The outermost layer, the epicardium, is the visceral layer of the serous pericardium, featuring a thin, transparent mesothelial surface and an inner layer of areolar connective tissue with fat deposits that increase with age.
The myocardium, the thickest layer, consists of cardiac muscle cells interconnected by intercalated discs and crisscrossing connective tissue fibers. These muscle fibers contract...
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Chambers of the Heart
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Deoxygenated blood from the body is received in the right...
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CHF can occur due to the failure of either side of the heart. Left-side failure leads to pulmonary congestion—the right side continues to send blood...
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The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
Chambers of the Heart
The heart is made up of four...
The heart has three layers: the innermost endocardium, the muscular myocardium, and the outer epicardium, all working together for optimal cardiac function.
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The heart is made up of four...
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