局部来源维持心房动,由先前除组织
Michel Haïssaguerre1, Mélèze Hocini, Prashanthan Sanders
1Hôpital Cardiologique du Haut-Lévêque, University Victor Segalen, Bordeaux, France. jacques.clementy@pu.u-bordeaux2.fr
Circulation
|February 8, 2006
概括
在废除后,可以绘制和废除导致心房动 (AF) 的局部来源. 这些来源,通常在左心室,可以使用先进的绘图技术来识别,为持久性AF提供新的治疗策略.
科学领域:
- 心脏病学 心脏病学
- 电力生理学 电力生理学
- 医疗器械 医疗器械
背景情况:
- 在人类中驱动心房动 (AF) 的局部来源的内心图谱以前没有报告过.
- 经过切除后的持续性AF是一个重大的临床挑战.
- 了解AF的起源对于有效治疗至关重要.
研究的目的:
- 为了调查存在和特征的局部来源驱动心房动 (AF) 在患者之前的废除.
- 为了确定这些来源是否可以使用内心图谱识别.
- 评估消除这些已识别的来源的可行性.
主要方法:
- 研究了50名患有组织性心房动 (AF) 的肺静脉和线性切除后患者.
- 使用先进的内心图谱技术来确定激活序列和潜在来源.
- 在已识别的源处进行了局部射频除.
主要成果:
- 在76%的患者中,发现了1到3个局部来源,主要在左前庭.
- 源处的电图显示离散的离心机激活或复杂的局部导电/再入.
- 源的射频消去延长了AF周期的长度,并在许多情况下终止或改变了节奏.
结论:
- 在先前切除后驱动AF的局部来源可以被映射和切除.
- 一些已识别的来源显示了电图,表明局部重新进入.
- 这项研究表明,药物耐药性AF的潜在新治疗标.
相关概念视频
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