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心血管疾病中的组织因子:分子机制和临床影响
Jan Steffel1, Thomas F Lüscher, Felix C Tanner
1Cardiovascular Research, Physiology Institute, Center for Integrative Human Physiology, University of Zürich, Zürich, Switzerland.
Circulation
|February 8, 2006
概括
组织因子 (TF) 启动血液凝固,并与心血管疾病有关. 抑制TF为治疗这些疾病提供了一个有前途的治疗策略.
科学领域:
- 生物化学 生物化学
- 血管生物学 血管生物学
- 心血管医学 心血管医学
背景情况:
- 组织因子 (TF) 是凝血级联的主要发起者,结合因子VIIa激活因子IX和X,导致纤维素形成.
- 在内皮细胞,光滑肌细胞和单细胞中,TF表达可通过各种刺激通过MAP激酶和PI3-激酶等信号通路诱导.
- 细胞TF存在于表面,加密和细胞内池中,循环TF也可以在血液中检测到.
研究的目的:
- 审查组织因子 (TF) 在凝血和心血管疾病发病过程中的作用.
- 探索TF的信号机制和蜂池.
- 讨论针对心血管疾病治疗TF的治疗策略.
主要方法:
- 关于TF在凝血和心血管疾病中的作用的文献综述.
- 分析TF表达,活动和信号通路的分析.
- 检查针对TF的治疗干预措施.
主要成果:
- 升高的TF水平与心血管风险因素 (高血压,糖尿病,失脂症,吸烟) 和急性冠状动脉综合征有关.
- 通过促进血栓形成和血管光滑肌肉细胞迁移/增殖,TF有助于动脉样硬化.
- 治疗策略包括抗TF抗体,修饰因子VIIa和TF路径抑制剂.
结论:
- TF是凝血的关键启动剂,是心血管疾病发病的一个重要因素.
- 针对性TF行动代表了对心血管疾病的有希望的治疗途径.
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