循环类的罗塔克桑
Vincent Aucagne1, David A Leigh, Julia S Lock
1University of Edinburgh, School of Chemistry, The King's Buildings, West Mains Road, Edinburgh EH9 3JJ, UK.
Journal of the American Chemical Society
|February 9, 2006
概括
研究人员使用类宏循环cyclo (l-ProGly) 4和cyclo (l-ProGly) 5.2合成了罗塔克桑. 这些复杂的分子以良好的产量形成,即使宏观循环内的内部键被破坏.
科学领域:
- 超分子化学 超分子化学
- 有机合成 有机合成
- 类化学 类化学
背景情况:
- 罗塔克桑是机械互锁的分子架构,在分子机器中具有潜在的应用.
- 类宏循环为超分子组装提供独特的结构和功能性质.
- 宏观循环中的内部结可以影响它们的结构灵活性和反应性.
研究的目的:
- 通过使用特定的类宏循环合成新型轮素.
- 为了研究从循环 ((l-ProGly) 4和循环 ((l-ProGly) 5宏循环和二线中形成罗塔克桑的过程.
- 为了评估合成的罗塔克桑的产量和结构完整性.
主要方法:
- 罗塔克桑的模板导向合成.
- 使用循环1 - 基4和循环1 - 基5作为宏观循环成分.
- 使用二衍生物作为分子线程.
主要成果:
- 罗塔克桑的成功合成得到了良好的产量,从56%到63%不等.
- 罗塔克桑的形成发生了尽管固有的破坏内部氨基胺-氨基胺结合在的宏循环.
- 这项研究表明,从基于的宏循环中构建复杂的轮素架构的可行性.
结论:
- 类宏循环,包括cyclo{l-ProGly) 4和cyclo{l-ProGly) 5,可以作为罗他素合成的有效成分.
- 合成策略允许形成轮素,即使在宏循环内的非共价相互作用受到损害时也是如此.
- 这项工作扩大了可访问的轮素结构的范围,并突出了在超分子化学中类宏循环的多功能性.
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