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通过双点相互作用,有效地破坏使用Zn(II) 二聚胺基人工受体的脂蛋白-蛋白表面相互作用

Akio Ojida1, Masa-aki Inoue, Yasuko Mito-oka

  • 1Department of Synthetic Chemistry and Biological Chemistry, Graduate School of Engineering, Kyoto University, Katsura, Kyoto, 615-8510, Japan.

Journal of the American Chemical Society
|February 9, 2006
PubMed
概括

研究人员开发了结合双酸化的小分子,破坏了蛋白与蛋白的相互作用. 这种新的策略显示出创造蛋白质信号通路的向抑制剂的前景.

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