疏水性和疏水性横井作为水中的受体
Sidhanath Bhosale1, Sheshanath Bhosale, Tianyu Wang
1Institut für Chemie/Organische Chemie, Takustrasse 3, D-14195 Berlin, Germany.
Journal of the American Chemical Society
|February 16, 2006
概括
新的水友性洞有效地将抗生素托布拉米辛在水中捕获. 相比之下,疏水的井使纤维素不动,为有针对性的输送应用展示了不同的分子相互作用.
科学领域:
- 超分子化学 超分子化学
- 纳米技术 纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 纳米尺度容器的yoctowells提供了分子封装的潜力.
- 量身定制井表面化学是选择性分子结合的关键.
- 了解yoctowells和特定分子之间的相互作用是应用的关键.
研究的目的:
- 为了引入新型的水友性乳酸盐井与脂乙烯基醇 (OEG) 壁.
- 为了研究托布拉米辛的选择性捕获和水友性约克与蜂菌的相互作用.
- 为了比较水友性约克托维尔与相应的疏水性约克托维尔的行为.
主要方法:
- 合成和描述具有OEG墙壁的水友性横井.
- 使用诸如异热定位热量计等技术测量托布拉米的结合亲和力.
- 在水溶液中对yoctowell与托布拉米辛和蜂糖的相互作用进行比较研究.
主要成果:
- 水友性约克托 (10^-24 L) 显示出高亲和度的托布拉米辛 (结合常数为10^7 M^-1) 的捕获.
- 水友性约克托韦尔与蜂菌没有相互作用.
- 疏水性约克托韦尔可以动态固定细胞菌,但不能捕获托布拉米辛.
结论:
- 具有OEG墙壁的水友性横井提供了一个选择性捕获多布拉米的平台.
- 含有多布拉米和纤维素的水友和疏水性约克托韦尔的明显相互作用突出了可调节的分子识别能力.
- 这些发现表明,在向药物输送和分子分离技术中,有潜在的洞.
相关概念视频
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