Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Types of Selection01:46

Types of Selection

Natural selection influences the frequencies of particular alleles and phenotypes within populations in several different ways. Primarily, natural selection can be directional, stabilizing, or disruptive. Directional selection favors one extreme trait and shifts the population towards that phenotype while selecting against individuals displaying alternate traits. Stabilizing selection favors an intermediate trait with a narrow range of variation. Deviation from the optimal phenotype towards an...
Law of Independent Assortment02:03

Law of Independent Assortment

While Mendel’s Law of Segregation states that the two alleles for one gene are separated into different gametes, a different question of how different genes are inherited remains. For example, is the gene for tall plants inherited with the gene for green peas? Mendel asked this question by experimenting with a dihybrid cross; a cross in which both parents are homozygous for two distinct traits resulting in an F1 generation that are heterozygous for both traits.
Woodward–Hoffmann Selection Rules and Microscopic Reversibility01:34

Woodward–Hoffmann Selection Rules and Microscopic Reversibility

Electrocyclic reactions, cycloadditions, and sigmatropic rearrangements are concerted pericyclic reactions that proceed via a cyclic transition state. These reactions are stereospecific and regioselective. The stereochemistry of the products depends on the symmetry characteristics of the interacting orbitals and the reaction conditions. Accordingly, pericyclic reactions are classified as either symmetry-allowed or symmetry-forbidden. Woodward and Hoffmann presented the selection criteria for...
Choosing Between z and t Distribution01:25

Choosing Between z and t Distribution

The z and the Student t distribution estimate the population mean using the sample mean and standard deviation. However, to decide which distribution to use for a calculation, one needs to determine the sample size, the nature of the distribution, and whether the population standard deviation is known. If the population standard deviation is known and the population is normally distributed, or if the sample size is greater than 30, the z distribution is preferred. The Student t distribution is...
Decision Making: P-value Method01:09

Decision Making: P-value Method

The process of hypothesis testing based on the P-value method includes calculating the P- value using the sample data and interpreting it.
First, a specific claim about the population parameter is proposed. The claim is based on the research question and is stated in a simple form. Further, an opposing statement to the claim  is also stated. These statements can act as null and alternative hypotheses:  a null hypothesis would be a neutral statement while the alternative hypothesis can have a...
Switching of BJT01:22

Switching of BJT

Switching behavior in Bipolar Junction Transistors (BJTs) is a fundamental aspect utilized in various electronic circuits, particularly for digital logic applications like switches and amplifiers. In a typical switching circuit, a BJT alternates between cut-off and saturation modes, corresponding to the "off" and "on" states, respectively, thus behaving like an ideal switch.
Cut-off Mode ("Off" State): In this state, both the emitter-base and collector-base junctions are reverse-biased. The...

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

<sup>19</sup>F-NMR spectroscopy of fluorinated isoleucine analogues in a protein.

Journal of biomolecular NMR·2026
Same author

Asymmetric Partial Reductions of Pyridines.

Trends in chemistry·2025
Same author

Targeting Mitochondrial Reactive Oxygen Species: JP4-039's Potential as a Cardiovascular Therapeutic.

Journal of clinical medicine·2025
Same author

Discovery and validation of small molecule stabilizers of mutant triose phosphate isomerase (TPI) as potential lead candidates for TPI deficiency.

SLAS discovery : advancing life sciences R & D·2025
Same author

<i>In vivo</i> manipulation of the protein homeostasis network in rhabdomyosarcoma.

Oncotarget·2025
Same author

Antitumor Efficacy of 1,2,4-Triazole-Based VCP/p97 Allosteric Inhibitors.

Journal of medicinal chemistry·2025

相关实验视频

Updated: Jul 12, 2026

Primer-Free Aptamer Selection Using A Random DNA Library
11:14

Primer-Free Aptamer Selection Using A Random DNA Library

Published on: July 26, 2010

一种用于奇拉选择器的选方法,不需要共价接.

Zhi Chen1, Yanhong Yang, Stefan Werner

  • 1Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.

Journal of the American Chemical Society
|February 16, 2006
PubMed
概括

一种新的高通量选方法通过测量液相之间的目标分布来识别奇拉选择器. 这种方法有效地选具有性选择性的化合物,而无需共价键.

科学领域:

  • 分析化学 分析化学
  • 有机化学 有机化学
  • 分离科学 分离科学

背景情况:

  • 状选择器的发现对于酶分离至关重要.
  • 现有的方法可能耗时,需要大量的材料.
  • 对于新性选择器,存在对高效,高通量选协议的需求.

研究的目的:

  • 开发和验证一种高通量选协议,用于识别性选择器.
  • 为了使基于非共价性分子间关联的选择器的发现.
  • 为了促进小分子图书馆的选,以寻找奇拉识别能力.

主要方法:

  • 一个基于生物查的高通量查协议.
  • 分区实验测量水和有机相之间的目标分布 (塑化聚乙烯化物).
  • 使用96孔板进行快速分区比测量.

主要成果:

  • 该协议使用已知的合性目标/选择器对进行了验证.
  • 选12个环二异质素对种族性econazole的检测.
  • 八种化合物显示与种族性标结合,其中一种化合物表现出可测量的性选择性.

结论:

更多相关视频

Selective Harvesting of Marginating-pulmonary Leukocytes
07:06

Selective Harvesting of Marginating-pulmonary Leukocytes

Published on: March 11, 2016

Selective Harvesting of Marginating-hepatic Leukocytes
06:53

Selective Harvesting of Marginating-hepatic Leukocytes

Published on: July 21, 2016

相关实验视频

Last Updated: Jul 12, 2026

Primer-Free Aptamer Selection Using A Random DNA Library
11:14

Primer-Free Aptamer Selection Using A Random DNA Library

Published on: July 26, 2010

Selective Harvesting of Marginating-pulmonary Leukocytes
07:06

Selective Harvesting of Marginating-pulmonary Leukocytes

Published on: March 11, 2016

Selective Harvesting of Marginating-hepatic Leukocytes
06:53

Selective Harvesting of Marginating-hepatic Leukocytes

Published on: July 21, 2016

  • 提出的高通量选方法对合选择器发现有效.
  • 该协议不要求对分析剂或选择器进行共价附着.
  • 该方法需要最小的数量 (约. 100μg) 的潜在性选择器.