类与类的类的反应
Thiruvellore Thatai Jayanth1, Masilamani Jeganmohan, Mu-Jeng Cheng
1Department of Chemistry, Tsing Hua University, Hsinchu 30013, Taiwan.
Journal of the American Chemical Society
|February 16, 2006
概括
类与类通过反应反应,形成替代的类. 这种方法有效地利用各种基和基合成烯.
科学领域:
- 有机化学 有机化学
- 合成方法论 合成方法论
背景情况:
- 阿林是有机合成中至关重要的高度反应性的中间体.
- 开发有效的烯循环添加反应方法是一个正在进行的研究领域.
研究的目的:
- 为了研究阿里因与基因的反应.
- 开发一种新型的合成路径,以替代类.
主要方法:
- 在正位生成从正位-silylaryl三酸盐的arynes.
- 使用THF的KF/18-皇冠-6与具有基的基反应.
- 探索各种终端和内部基和基.
主要成果:
- 替代的类在良好的中等产量中成功合成.
- 反应是多功能性的,可以容纳多种基和基基质.
- 缺少propargylic的基产生了乙烯基C-H添加和脱水的Diels-Alder产物.
结论:
- 氨酸反应为合成氨酸提供了一条有效的途径.
- 反应的结果取决于基结构,提供替代产品.
- 这项研究扩大了aryne化学的合成效用.
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