氧化DNA/RNA修复酶AlkB的催化复合物的晶体结构

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Updated: Jul 14, 2026

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair
10:59

Atomic Force Microscopy Investigations of DNA Lesion Recognition in Nucleotide Excision Repair

Published on: May 24, 2017

Bomina Yu1, William C Edstrom, Jordi Benach

  • 1Department of Biological Sciences and Northeast Structural Genomics Consortium, 702A Fairchild Center, MC2434, Columbia University, New York, New York 10027, USA.

Nature
|February 17, 2006
PubMed
概括

大肠杆菌AlkB可以修复基化核酸. 晶体结构揭示了结合基质的柔性盖子,使得DNA和RNA的修复效率高. 蛋白质动态影响其催化活性.

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Nucleotide Excision Repair01:08

Nucleotide Excision Repair

Overview
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Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...
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Long-patch Base Excision Repair

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Fixing Double-strand Breaks02:04

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...
Homologous Recombination02:31

Homologous Recombination

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Nucleic Acid Structure

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DNA Structure
DNA has a double-helix structure. The...