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General Transcription Factors

General Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...

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Updated: Jul 14, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

纤毛神经变因子的受体.

S Davis¹, T H Aldrich, D M Valenzuela

¹Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.

Science (New York, N.Y.)

|July 5, 1991

概括

研究人员确定了一种新型的纤毛神经营养因子 (CNTF) 受体. 这种对神经系统发育至关重要的CNTF受体在结构上是独一无二的,并通过一种甘氨酸-酸氨基醇链接固定在细胞膜上.

科学领域:

神经科学是一个神经科学.
分子生物学分子生物学
细胞生物学细胞生物学

背景情况:

神经营养不良因素对于神经系统的发展和维护至关重要.
了解神经营养因子受体是阐明它们的作用机制和细胞的关键.

研究的目的:

识别和描述纤毛神经营养因子 (CNTF) 的受体.
了解CNTF受体的结构和细胞特性.

主要方法:

采用了"标记联结子选"程序来克隆CNTF受体.
分析了鉴定受体的表达模式和结构同质性.

主要成果:

CNTF受体仅在神经系统和骨肌肉中表达.
它的结构与神经生长因子受体无关,但与互白素-6受体同源,这表明需要第二个信号传导元件.
CNTF受体通过一种新的特征,通过糖系-酸氨基醇链接在细胞膜上.

结论:

新型CNTF受体在神经系统和骨肌肉中起着重要作用.
它的独特结构和膜 anchoring 机制为神经营养因子信号通路提供了新的见解.

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Published on: September 15, 2014

Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings

Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings

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Last Updated: Jul 14, 2026

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Genetic Manipulation of Cerebellar Granule Neurons In Vitro and In Vivo to Study Neuronal Morphology and Migration

Published on: March 17, 2014

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Real-time Imaging of Axonal Transport of Quantum Dot-labeled BDNF in Primary Neurons

Published on: September 15, 2014

Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings

Combined Recording of Mechanically Stimulated Afferent Output and Nerve Terminal Labelling in Mouse Hair Follicle Lanceolate Endings

Published on: May 7, 2016