过渡到无性行为导致过多的氨基酸替代
Susanne Paland1, Michael Lynch
1Department of Biology, Indiana University, 1001 East 3rd Street, Bloomington, IN 47405, USA. spaland@indiana.edu
概括
无性繁殖加速了线粒体基因中有害突变的积累. 性繁殖对于清除这些突变和保持遗传健康至关重要.
科学领域:
- 进化生物学 进化生物学
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 遗传联系可能会损害净化选择的有效性.
- 无性血统,具有永久链接的基因,可能会在核和器官DNA中积累更多有害的突变.
研究的目的:
- 研究无性繁殖对线粒体蛋白质编码基因突变积累的影响.
- 为了比较无性和性血统之间的有害氨基酸替代率.
主要方法:
- 在Daphnia pulex的线粒体蛋白质编码基因中分析了氨基酸与静态替代率 (Ka/Ks) 的比率.
- 采用基于系系学的方法来分类和量化突变效应.
主要成果:
- 与性系相比,强制无性Daphnia pulex血统在线粒体基因中的Ka/Ks比率较高.
- 无性血统中的线粒体基因在估计性血统中观察到的速率的四倍左右积累有害的氨基酸替代.
结论:
- 性繁殖在减轻种群内的突变负担方面发挥着重要作用.
- 无性繁殖加剧了有害突变的积累,特别是在线粒体基因组中.
相关概念视频
Mutations
Overview
Urea Cycle
The urea cycle describes how liver cells convert ammonia to urea. Ammonia is a toxic waste product of protein catabolism. Land animals must convert ammonia into the less toxic urea which can be safely eliminated by the kidneys through urine. Marine animals excrete ammonia directly, and the surrounding water dilutes the ammonia to safe levels.
Comparative Excretory Systems
Animals have evolved different strategies for excretion, the removal of waste from the body. Most waste must be dissolved in water to be excreted, so an animal’s excretory strategy directly affects its water balance.
Overview of Nitrogen Metabolism
Nitrogen is a very important element for life because it is a major constituent of proteins and nucleic acids. It is a macronutrient, and in nature, it is recycled from organic compounds and stored in the form of ammonia, ammonium ions, nitrate, nitrite, or nitrogen gas by many metabolic processes. Many of these metabolic processes are carried out only by prokaryotes.
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this nitrogen...
The largest pool of nitrogen available in the terrestrial ecosystem is gaseous nitrogen (N2) from the air, but this nitrogen...
Mutations
Mutations are changes in the sequence of DNA. These changes can occur spontaneously or they can be induced by exposure to environmental factors. Mutations can be characterized in a number of different ways: whether and how they alter the amino acid sequence of the protein, whether they occur over a small or large area of DNA, and whether they occur in somatic cells or germline cells.
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Chromosomal Alterations Are Large-Scale Mutations
While point mutations are changes in a single nucleotide in...
Amino Acid Catabolism
Microorganisms rely on proteins as an essential carbon and energy source, particularly in environments with limited polysaccharides or lipids. However, proteins are too large to cross the plasma membrane unaided, necessitating enzymatic degradation. Microbes secrete extracellular proteases and peptidases that hydrolyze proteins into peptides, which can then be transported across the membrane. Once inside the cell, intracellular proteases degrade these peptides into free amino acids, which...


