男性的乳腺癌是男性的乳腺癌
Ian S Fentiman1, Alain Fourquet, Gabriel N Hortobagyi
1Academic Oncology, Thomas Guy House, Guy's Hospital, London SE1 9RT, UK. Ian.Fentiman@gstt.nhs.uk
Lancet (London, England)
|February 21, 2006
概括
通常在71岁时被诊断为男性乳腺癌,与BRCA2突变和高雌激素化有关. 早期检测至关重要,因为大多数病例存在于晚期.
科学领域:
- 在瘤学瘤学.
- 遗传学 是一个遗传学.
- 流行病学 流行病学
背景情况:
- 男性乳腺癌是一种罕见的疾病,发病率在71岁左右达到峰值.
- 家庭病例与BRCA2突变相比,与BRCA1.1突变相比更常见.
- 风险因素包括过度雌激素化 (克莱因菲尔特病,肥胖,酒精) 和辐射暴露.
研究的目的:
- 总结男性乳腺癌的流行病学,风险因素,表现和管理.
- 强调早期检测和适当的治疗策略的重要性.
主要方法:
- 对男性乳腺癌现有文献的综述.
- 风险因素,临床表现,病理和治疗结果的分析.
主要成果:
- 常见的表现包括块或乳头倒置,通常在晚期 (III/IV).
- 大多数瘤都是管道瘤,10%是管道瘤 in situ.
- 雌激素受体阳性瘤 (90%) 对他莫西芬和激素治疗反应良好.
结论:
- 男性乳腺癌的治疗方法与女性乳腺癌相似,手术,放射治疗和激素治疗是主要的支柱.
- 化疗可能对一些患者有益,特别是转移性疾病.
- 需要改善国家对男性乳腺癌患者的支持和信息举措.
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