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相关概念视频

Chirality at Nitrogen, Phosphorus, and Sulfur02:30

Chirality at Nitrogen, Phosphorus, and Sulfur

Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
Structure and Nomenclature of Thiols and Sulfides02:17

Structure and Nomenclature of Thiols and Sulfides

Thiols and sulfides are sulfur analogs of alcohols and ethers, respectively, where the sulfur atom takes the place of the oxygen atom. Thus, thiols are generally represented as RSH, where R is an alkyl substituent and —SH is the functional group. On the other hand, in sulfides, the central sulfur atom is bonded to two hydrocarbon groups on either side. Depending upon the type of group, sulfides can be either symmetrical or asymmetrical. Both thiols and sulfides display a bent geometry, similar...
Preparation and Reactions of Thiols02:33

Preparation and Reactions of Thiols

Thiols are prepared using the hydrosulfide anion as a nucleophile in a nucleophilic substitution reaction with alkyl halides. For instance, bromobutane reacts with sodium hydrosulfide to give butanethiol.
Preparation and Reactions of Sulfides02:26

Preparation and Reactions of Sulfides

Sulfides are the sulfur analog of ethers, just as thiols are the sulfur analog of alcohol. Like ethers, sulfides also consist of two hydrocarbon groups bonded to the central sulfur atom. Depending upon the type of groups present, sulfides can be symmetrical or asymmetrical. Symmetrical sulfides can be prepared via an SN2 reaction between 2 equivalents of an alkyl halide and one equivalent of sodium sulfide.
2° Amines to N-Nitrosamines: Reaction with NaNO201:20

2° Amines to N-Nitrosamines: Reaction with NaNO2

Secondary amines react with nitrous acid to form N-nitrosamines, as depicted in Figure 1. Nitrous acid, a weak and unstable acid, is formed in situ from an aqueous solution of sodium nitrite and strong acids, such as hydrochloric acid or sulfuric acid, in cold conditions. In the presence of an acid, the nitrous acid gets protonated. The subsequent loss of water results in the formation of the electrophile known as nitrosonium ion.
Nitrosation of Enols01:19

Nitrosation of Enols

The nitrosation reaction is one of the methods of preparing 1,2-diketones. The enol tautomer of the starting ketone reacts with sodium nitrite in hydrochloric acid, generating the 1,2-diketone after hydrolysis.

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相关实验视频

Updated: Jul 6, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
12:05

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies

Published on: March 6, 2013

一个令人惊的稳定的S-nitrosothiol复合体.

Laura L Perissinotti1, Darío A Estrin, Gregory Leitus

  • 1Departamento de Química Inorgánica, Analítica y Química Física/INQUIMAE-CONICET, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, Argentina.

Journal of the American Chemical Society
|February 24, 2006
PubMed
概括
此摘要是机器生成的。

研究人员通过K[IrCl5NO]与甲的反应合成和表征了第一个稳定,协调的S-甲复合物,trans-K[IrCl4(CH3CN) N(O) SCH2Ph. 这一发现为协调化学和有机金属化合物研究开辟了新的途径.

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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates

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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
08:23

Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

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Last Updated: Jul 6, 2026

Production of Disulfide-stabilized Transmembrane Peptide Complexes for Structural Studies
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Synthesis and Bioconjugation of Thiol-Reactive Reagents for the Creation of Site-Selectively Modified Immunoconjugates
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds
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Chemiluminescence-based Assays for Detection of Nitric Oxide and its Derivatives from Autoxidation and Nitrosated Compounds

Published on: February 16, 2022

科学领域:

  • 无机化学 无机化学
  • 协调化学 协调化学
  • 有机金属化学 有机金属化学

背景情况:

  • 在生物系统中,s-nitrosothiols是重要的,但往往是不稳定的.
  • 协调的S-尼特罗斯醇很难合成和分离.
  • 以前的研究没有报告稳定,可分离的协调S-nitrosothiols.

研究的目的:

  • 为了合成和表征一种新的协调S-nitrosothiol复合物.
  • 为了研究协调复合体中S-尼托索醇配体的稳定性和反应性.
  • 为隔离这些化合物树立先例.

主要方法:

  • 五尼四利酸 (K[IrCl5NO]) 与甲在酸中发生的反应.
  • 分离和净化由此产生的复合物.
  • 使用里埃变换红外光谱法 (FTIR),质子核磁共振 (1H NMR) 和电喷离子质谱法 (ESI-MS) 进行了表征.

主要成果:

  • 成功合成了一种惊人的稳定性S-尼特罗斯醇复合物,转基[IrCl4(CH3CN) N(O) SCH2Ph].
  • 综合体在高产量的隔离 (80%).
  • 完整的表征证实了拟议的结构和稳定性.

结论:

  • 这项研究报告了首次分离协调的S-nitrosothiol.
  • 合成的复合物表现出意想不到的稳定性,这表明了S-nitrosothiol化学的新可能性.
  • 这项工作为进一步探索S-尼特罗斯醇协调复合体提供了基础.