Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

What is the Immune System?01:38

What is the Immune System?

99.2K
Overview
99.2K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

64.7K
Overview
64.7K
Cells of the Innate Immune Response01:28

Cells of the Innate Immune Response

8.4K
The innate immune response is an immediate and non-specific response against pathogens, acting swiftly to prevent the spread of infections. The primary cells involved in this response are phagocytes and natural killer (NK) cells.
Phagocytes
Phagocytes police the peripheral tissues by removing cellular debris and responding to the invasion of foreign substances or pathogens. Many phagocytes attack and remove microorganisms even before lymphocytes detect them. The human body has two general...
8.4K
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

1.7K
An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
1.7K
Diversity of Antigen Receptors01:28

Diversity of Antigen Receptors

2.1K
Antigen receptors are essential components of the immune system crucial in defending the body against foreign invaders. These receptors are present on the surface of B and T cells, enabling them to recognize antigens and mount an appropriate immune response.
Before encountering any antigen, lymphocytes express these receptors. On B cells, the antigen receptor is a membrane-bound antibody molecule called BCR; on T cells, it is a T cell receptor or TCR. B and T cell receptors are composed of two...
2.1K
Immune Response Against Viral Pathogens01:29

Immune Response Against Viral Pathogens

2.4K
The immune system's response to viral infections is a complex and coordinated process involving natural killer (NK) cells, T cell-mediated responses, and antibody-mediated responses.
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
2.4K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Human DHX29 detects nonoptimal codon usage to regulate mRNA stability.

Science (New York, N.Y.)·2026
Same author

A peripheral neurons-basophil axis drives heat-killed Staphylococcus aureus-induced dermatitis through toll-like receptor 2 signaling pathway.

The Journal of investigative dermatology·2026
Same author

Regnase-1-mediated regulation of neutrophils modulates SARS-CoV-2 pneumonia.

PLoS pathogens·2026
Same author

Anti-Integrin αvβ6 Autoantibodies Predict Response and Treatment Persistence to Advanced Therapies in Ulcerative Colitis.

Clinical and translational gastroenterology·2026
Same author

Regnase-1 in cDC1 controls T cell priming and shapes the dynamics of experimental autoimmune encephalomyelitis.

Frontiers in immunology·2026
Same author

Extracellular vesicles derived from adipose-derived mesenchymal stem/stromal cells prevent synovial inflammation and attenuate cartilage degeneration in rodent osteoarthritis.

Regenerative therapy·2026
Same journal

A viral ORFeome library for systems-level genetic dissection of host-pathogen interactions.

Cell·2026
Same journal

Co-option of lysosomal machinery shapes the evolution of the intracellular photosymbiosis supporting coral reefs.

Cell·2026
Same journal

LEF1 and niche factors determine T cell stemness across chronic diseases.

Cell·2026
Same journal

Recurrent patterns of TOP1-mediated neuronal genomic damage shared by major neurodegenerative disorders.

Cell·2026
Same journal

Four-dimensional molecular mapping from a spatial snapshot reveals the dynamics of hair follicle organogenesis.

Cell·2026
Same journal

Whole-cell particle-based digital twin simulations from 4D lattice light-sheet microscopy data.

Cell·2026
查看所有相关文章

相关实验视频

Updated: May 4, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

11.1K

病原体识别和天生的免疫力

Shizuo Akira1, Satoshi Uematsu, Osamu Takeuchi

  • 1Department of Host Defense, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan. sakira@biken.osaka-u.ac.jp

Cell
|February 25, 2006
PubMed
概括
此摘要是机器生成的。

天生的免疫系统使用模式识别受体 (PRR) 来检测入侵的微生物. 这种识别触发了激活免疫细胞和基因表达的信号通路,影响了疾病治疗.

更多相关视频

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay
05:15

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay

Published on: February 10, 2022

4.5K
Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.8K

相关实验视频

Last Updated: May 4, 2026

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector
08:10

Simultaneous Quantification of Anti-vector and Anti-transgene-Specific CD8+ T Cells Via MHC I Tetramer Staining After Vaccination with a Viral Vector

Published on: November 28, 2018

11.1K
Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay
05:15

Detection of Neutralization-sensitive Epitopes in Antigens Displayed on Virus-Like Particle VLP-Based Vaccines Using a Capture Assay

Published on: February 10, 2022

4.5K
Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers
09:15

Author Spotlight: Optimized Protocol for Detecting Antigen-Specific T Cells in Mouse Lungs Using Tetramers

Published on: July 19, 2024

1.8K

科学领域:

  • 免疫学 免疫学 免疫学
  • 微生物学 微生物学
  • 分子生物学分子生物学

背景情况:

  • 脊椎动物的先天免疫依赖于生殖系编码的模式识别受体 (PRRs) 进行初始微生物检测.
  • PRRs,如Toll类受体和细胞质受体,识别特定的微生物组成部分.
  • 激活PRRs可以启动细胞内信号级联.

研究的目的:

  • 要总结当前对天生的免疫机制的理解.
  • 突出PRRs在微生物识别和免疫细胞激活中的作用.
  • 讨论有关先天性免疫的新见解对疾病发病和治疗的影响.

主要方法:

  • 对有关先天免疫和PRRs的现有文献的审查.
  • 通过PRR-连接物相互作用激活的信号通路的分析.
  • 在免疫细胞刺激后,对基因表达模式的信息的合成.

主要成果:

  • PRRs识别了保存的微生物分子模式,启动了免疫反应.
  • 与PRRs结合的联体触发了快速的细胞内信号级联.
  • 这些级联诱导重叠和独特的基因表达特征,协调炎症和免疫力.

结论:

  • 关于天生的免疫力的新发现从根本上改变了我们对疾病的理解.
  • 这些见解为传染病,过敏和自身免疫性疾病提供了新的治疗策略.
  • 微生物成分和PRR之间的复杂相互作用是宿主防御和疾病发展的核心.