内子和核-细胞醇分隔的起源
William Martin1, Eugene V Koonin
1Institute of Botany III, University of Düsseldorf, D-40225 Düsseldorf, Germany. w.martin@uni-duesseldorf.de
Nature
|March 3, 2006
概括
细胞核很可能进化为缓慢的mRNA拼接快速翻译之前,确保精确的蛋白质合成. 这种细分是由线粒体起源后的内子传播驱动的.
科学领域:
- 进化生物学是进化的生物学.
- 分子生物学分子生物学
- 细胞生物学 细胞生物学
背景情况:
- 细胞核的起源是进化历史上的一个关键事件.
- 早期核膜的功能尚未完全理解.
- mRNA拼接和翻译是细胞的基本过程.
研究的目的:
- 为核外的初始功能提出一个新的假设.
- 将核的起源与内子和线粒体的进化联系起来.
- 为了解释驱动真核细胞分离的选择性压力.
主要方法:
- 这项研究主要是理论性的,提出了基于现有生物知识的假设.
- 它整合了进化生物学,分子遗传学和细胞生物学的概念.
- 这一论点得到了支持,引证了内子的扩散作为选择性压力.
主要成果:
- 核外的主要作用可能是使完整的mRNA拼接成为可能.
- 这种细分使得翻译只能在正确拼接的mRNA上发生.
- 线粒体起源后的内子的传播为核-细胞质分离创造了选择性的优势.
结论:
- 核膜的进化与需要精确基因表达的需求密切相关.
- 分区化为内部介导拼接所带来的挑战提供了解决方案.
- 线粒体的起源在推动真核核进化的过程中起到了至关重要的作用.
相关概念视频
Eukaryotic Compartmentalizations
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
For example, lysosomes in the animal cells...
The Nucleus
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Eukaryotic Compartmentalization
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
For example, lysosomes in the animal cells...
Additional Subnuclear Structures
The eukaryotic nucleus is a double membrane-bound organelle that contains nearly all of the cell’s genetic material in the form of chromosomes. It is rightly called the “brain” of the cell as it shoulders the responsibility of responding to various physiological processes, stress, altered metabolic conditions, and other cellular signals.
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
The nucleus contains many membrane-less subnuclear organelles or nuclear bodies, such as nucleoli, Cajal bodies, speckles, paraspeckles, etc. These nuclear...
Eukaryotic Compartmentalization
One of the distinguishing features of eukaryotic cells is that they contain membrane-bound organelles, such as the nucleus and mitochondria, that carry out specialized functions. Since biological membranes are only selectively permeable to solutes, they help create a compartment with controlled conditions inside an organelle. These microenvironments are tailored to the organelle's specific functions and help isolate them from the surrounding cytosol.
For example, lysosomes in the animal cells...
For example, lysosomes in the animal cells...
The Nucleus
The nucleus is a membrane-bound organelle that acts as a control center in a eukaryotic cell. It contains chromosomal DNA, which controls gene expression and precisely regulates the production of proteins within the cell. In contrast, the DNA inside the mitochondria and chloroplast only carries out functions that are specific to those organelles.
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...
Arrangement of DNA within Nucleus
The regulation of gene expression inside the nucleus is dependent on many factors, including the DNA structure. The...


