航空旅行期间凝血系统的激活:一个交叉研究
A J M Schreijer1, S C Cannegieter, J C M Meijers
1Department of Vascular Medicine, Academic Medical Center, Amsterdam, Netherlands.
Lancet (London, England)
|March 15, 2006
概括
空中旅行会导致血液高凝血,增加血栓形成的风险. 这项研究发现,8小时的飞行在一些人中激活了凝血标记,这表明了一种超出不动性的机制.
科学领域:
- 心血管生理学心血管生理学
- 血液学 血液学 血液学
- 血栓形成的研究研究.
背景情况:
- 航空旅行与静脉血栓形成的风险增加有关.
- 导致这种风险增加的精确生理机制尚不完全理解.
研究的目的:
- 调查航空旅行是否会在健康个体中诱导高凝血状态.
- 为了区分空中旅行的影响与不运动和昼夜节律中断.
主要方法:
- 一项涉及71名健康志愿者的交叉研究,这些志愿者接受了8小时的飞行,8小时的电影马拉松和日常生活.
- 在每次暴露之前,期间和之后测量凝血和纤维分解激活标记物 (前热片段1和2,热-抗热复合物,D-二分体).
- 包括患有血栓形成风险因素的参与者,如V因子莱登突变和口服避孕药的使用.
主要成果:
- 经过8小时的飞行后,中位数血-抗血复合物的度增加了30.1%,而在对照情况后的度下降.
- 很大一部分人 (17%) 在飞行后表现出高血-抗血水平的反应,特别是那些有V因子莱登突变和使用口服避孕药的人.
- 四名志愿者 (6.3%) 在飞行后在多种凝血标志物中表现出高反应,在对照条件下没有观察到此类反应.
结论:
- 8小时的飞行可以激活个人子集的凝血.
- 这种凝血的激活代表了一个额外的机制,超出不动,有助于航空旅行相关的血栓形成的风险.
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