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相关概念视频

The Tumor Microenvironment02:17

The Tumor Microenvironment

Every normal cell or tissue is embedded in a complex local environment called stroma, consisting of different cell types, a basal membrane, and blood vessels. As normal cells mutate and develop into cancer cells, their local environment also changes to allow cancer progression. The tumor microenvironment (TME) consists of a complex cellular matrix of stromal cells and the developing tumor. The cross-talk between cancer cells and surrounding stromal cells is critical to disrupt normal tissue...
Metastasis02:30

Metastasis

Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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相关实验视频

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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation
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Contrast Ultrasound Targeted Treatment of Gliomas in Mice via Drug-Bearing Nanoparticle Delivery and Microvascular Ablation

Published on: December 15, 2010

通过表面修饰的蛋白质微球向瘤.

Farah Jean-Jacques Toublan1, Stephen Boppart, Kenneth S Suslick

  • 1Department of Chemistry and Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 600 South Mathews Avenue, Urbana, Illinois 61801, USA.

Journal of the American Chemical Society
|March 16, 2006
PubMed
概括

研究人员开发了用于向癌症治疗的RGD改性蛋白质微球. 这些新型的微球证明了瘤细胞的选择性结合和吸收,克服了生物医学应用中以前的表面修饰挑战.

科学领域:

  • 生物材料科学 生物材料科学
  • 纳米技术 纳米技术
  • 在瘤学瘤学.

背景情况:

  • 蛋白质微球被用于生物医学成像和药物输送.
  • 针对目标细胞输送的表面修饰仍然是一个重大挑战.

研究的目的:

  • 开发一种用于将蛋白质微球准瘤细胞的新方法.
  • 调查用于表面功能化的静电粘合的使用.

主要方法:

  • 采用静电粘附方法将阿尔金氨-胺酸-酸 (RGD) 与血清白蛋白核心外微球连接起来.
  • 采用含有RGD序列的聚氨酸,用于表面修饰.
  • 在实验室中使用HT29人类结肠癌细胞进行了向研究.

主要成果:

  • 成功地用含有RGD的基因修改了血清白蛋白微球的表面.
  • 已证明修改后的微球对HT29结肠癌细胞的选择性结合.
  • 通过光显微镜确认癌细胞通过细胞吸收RGD修饰的微球.

结论:

  • 静电粘附是一种有效的策略,用于用RGD对蛋白质微球进行表面修饰.
  • 经RGD修改的蛋白质微球显示出有望的向向瘤细胞的向输送.

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Surface-enhanced Resonance Raman Scattering Nanoprobe Ratiometry for Detecting Microscopic Ovarian Cancer via Folate Receptor Targeting

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  • 这种方法为克服向癌症治疗的先前局限性提供了潜在的解决方案.