从会议摘要过渡到随机对照试验的全篇期刊文章
Mustafa Toma1, Finlay A McAlister, Liza Bialy
1The Division of General Internal Medicine, University of Alberta, Edmonton, Alberta, Canada.
JAMA
|March 16, 2006
概括
在科学会议上提出的晚期突破性随机对照试验 (RCT) 规模更大,发布速度更快,不太可能报告有利的结果. 然而,所有RCT的摘要和完整出版结果之间的差异是常见的.
科学领域:
- 心脏病学 心脏病学
- 临床试验 临床试验
- 科学出版科学出版
背景情况:
- 科学会议的演讲可能与已发表的研究不同.
- 随机对照试验 (RCT) 的出版命运和一致性从晚间突破会议并没有得到充分研究.
- 了解出版模式对于准确的科学解释至关重要.
研究的目的:
- 为了比较随机对照试验 (RCT),在晚间休息的会议中与其他会议在一个主要的科学会议.
- 评估这些RCT的出版命运和摘要与全篇文章之间的结果一致性.
主要方法:
- 美国心脏病学会科学会议 (1999-2002) 的手工搜索摘要和网站,以确定RCT.
- 利用电子数据库来识别后续的全长出版物.
- 比较出版率,出版时间,以及摘要和文章之间的有效性估计的一致性.
主要成果:
- 晚期突破的RCT较大,更有可能发表设计论文,并在发布时质量更高.
- 晚间突破性会议的RCT比其他会议的RCT更频繁,更早地发表.
- 摘要和出版物有效性估计之间的差异发生在41%的已发表的RCT中,晚期和其他会议的比例相似.
结论:
- 晚期突破性试验表现出明显的特征,包括更大的尺寸和更早的出版,但不一定更准确.
- 呈现和发表的结果之间的差异是一个常见的问题,即使对于晚期的试验.
- 对于所有随机对照试验,需要仔细比较抽象和完整的出版数据.
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