多轮的物种化与多类酵母中相互的基因丧失有关
Devin R Scannell1, Kevin P Byrne, Jonathan L Gordon
1Smurfit Institute of Genetics, University of Dublin, Trinity College, Dublin 2, Ireland.
Nature
|March 17, 2006
概括
酵母祖先的全基因组重复导致了基因丢失,推动了物种化. 在Saccharomyces cerevisiae,S. castellii和C. glabrata中,不同的基因丢失模式揭示了繁殖隔离和快速物种出现的机制.
科学领域:
- 进化生物学是进化的生物学.
- 基因组学就是基因组学.
- 酵母遗传学 酵母遗传学
背景情况:
- 在Saccharomyces cerevisiae,Saccharomyces castellii和Candida glabrata的祖先中发生了一个共享的全基因组重复事件.
- 在这种重复之后,随后的基因丢失模式在这三个酵母菌种之间有很大的差异.
研究的目的:
- 在相关的酵母物种中,研究在全基因组重复后重复基因的差异性损失.
- 探索基因丧失在物种化和生殖隔离中的作用.
- 提出一个统一的模型来解释基因损失如何推动酵母菌种类的快速出现.
主要方法:
- 在Saccharomyces cerevisiae,Saccharomyces castellii和Candida glabrata中对基因丢失模式的比较基因组分析.
- 鉴定因差异性基因丢失而产生的非正统基因.
- 对保留复制位置的基因功能和进化速率的分析.
主要成果:
- 在这三种物种中,在20%的基因位点中观察到基因损失的显著差异.
- 4-7%的单复制基因因因重复基因对的差异性损失而不是物种间的正义基因.
- 损失模式表明贝森-多布尚斯基-穆勒机制有助于生殖隔离.
- 保留的重复基因被丰富为核糖体生物发生和缓慢进化的基因.
结论:
- 整个基因组复制后的差异基因损失是酵母菌物种化的关键驱动因素.
- 被动基因损失可以迅速导致新物种的出现.
- 观察到的模式支持一种统一的基因损失驱动的酵母物种化模型.
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