Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

Glial Cells01:04

Glial Cells

75.3K
Overview
75.3K
TGF - β Signaling Pathway01:16

TGF - β Signaling Pathway

7.2K
The TGF-β signaling pathway regulates cell growth, differentiation, adhesion, motility, and development. TGF-β ligands that induce TGF-β signaling are synthesized in their latent form. Several proteases or cell surface receptors such as integrins act upon the latent form, releasing the active ligand. There are three types of mammalian TGF-βs: (TGF-β1, TGF-β2, and TGF-β3) that bind as homodimers or heterodimers to TGF-β receptors. The TGF-β receptors...
7.2K

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Transregional astrocyte-dependent metaplasticity in the hippocampus.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Advancing Clinical Translational Research for Profound Autism.

Biological psychiatry·2026
Same author

Local control of dopamine release in nucleus accumbens gates opioid withdrawal aversion.

bioRxiv : the preprint server for biology·2026
Same author

Dopamine and serotonin inversely modulate D2 medium spiny neurons to regulate cocaine reward.

Nature communications·2026
Same author

Serotonin modulates nucleus accumbens circuits to suppress aggression in mice.

Nature communications·2026
Same author

Cholinergic modulation of dopamine release drives effortful behaviour.

Nature·2026

相关实验视频

Updated: May 6, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K

通过质TNF-alpha介导的突触缩放.

David Stellwagen1, Robert C Malenka

  • 1Nancy Pritzker Laboratory, Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Palo Alto, California 94304-5485, USA.

Nature
|March 21, 2006
PubMed
概括

质细胞通过瘤死亡因子-α (TNF-α) 调节神经网络的稳定性. 这种炎症性细胞因子对于恒常性突触缩放至关重要,调整突触强度以保持最佳的大脑功能.

科学领域:

  • 神经科学是一个神经科学.
  • 细胞生物学 细胞生物学
  • 神经免疫学 神经免疫学

背景情况:

  • 突触可塑性在发育过程中提炼神经回路.
  • 长期强化 (LTP) 和长期抑郁 (LTD) 调整个人突触强度.
  • 恒常性突触缩放均调整细胞上的所有突触,对网络稳定至关重要.

研究的目的:

  • 调查基于同位素突触缩放的机制.
  • 识别突触缩放的分子介质,以应对活动阻塞.
  • 确定参与突触缩放的介质的细胞源.

主要方法:

  • 使用了野生类型和TNF-α缺乏的神经元和神经质的混合物.
  • 在长时间阻断神经元活动时,研究了突触缩放的反应.
  • 评估了瘤亡因子-α (TNF-α) 在突触缩放中的作用.

主要成果:

  • 证明瘤亡因子-α (TNF-α) 中介突触缩放.
  • 表明质细胞是突触缩放所需的TNF-alpha的来源.
  • 证实了TNF-alpha在突触强度的恒常调整中的作用.

结论:

更多相关视频

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
07:57

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

3.2K
Author Spotlight: Microglia Research on Spinal Cord Heterogeneity and Purification
04:15

Author Spotlight: Microglia Research on Spinal Cord Heterogeneity and Purification

Published on: September 22, 2023

2.3K

相关实验视频

Last Updated: May 6, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration
08:52

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

13.8K
Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration
07:57

Coculture of Axotomized Rat Retinal Ganglion Neurons with Olfactory Ensheathing Glia, as an In Vitro Model of Adult Axonal Regeneration

Published on: November 2, 2020

3.2K
Author Spotlight: Microglia Research on Spinal Cord Heterogeneity and Purification
04:15

Author Spotlight: Microglia Research on Spinal Cord Heterogeneity and Purification

Published on: September 22, 2023

2.3K
  • 质细胞积极调节神经网络的恒常性.
  • 瘤亡因子-α (TNF-α) 是同居性突触缩放的关键调解者.
  • 质细胞对TNF-alpha的调节对于活动依赖的突触连接的调节至关重要.