在女性和男性中,稳定性胸痛的发生率和预后影响
Harry Hemingway1, Alison McCallum, Martin Shipley
1Department of Epidemiology and Public Health, University College London Medical School, London, England. h.hemingway@ucl.ac.uk
JAMA
|March 23, 2006
概括
稳定性 angina 的发生率在男性和女性中是相似的. 虽然大多数人的预后是可比的,但患有测试阳性的胸痛的年轻女性比男性面临更高的死亡风险.
科学领域:
- 心脏病学 心脏病学
- 流行病学 流行病学
- 公共卫生 公共卫生
背景情况:
- 妇女的稳定性胸痛在历史上被认为不如男性严重,缺乏广泛的人口数据.
- 以前的假设表明,对于患有稳定性胸痛的女性,预后影响较小.
研究的目的:
- 调查稳定性 angina 的发生率和预后的基于性别的差异.
- 在一个庞大,多样化的门诊患者群体中分析稳定性 angina 的结果.
主要方法:
- 一个前性队列研究,利用芬兰的链接国家注册表.
- 包括45-89岁的门诊患者,没有先前冠状动脉疾病,通过酸盐处方或异常测试结果确定.
- 在2001年12月之前对冠状动脉死亡率和心肌梗塞事件的随访.
主要成果:
- 稳定性心痛的发病率在性别之间是可比的 (男性为2.03/100人年,女性为1.89/100人年).
- 与一般人群相比,酸盐心脏病对男女的冠状动脉死亡风险相似.
- 年龄较小的女性 (<75岁) 患有阳性胸痛,死亡率高于男性,有显著的相互作用 (P<.001).
- 女性中较高的酸盐剂量与与男性相似的预后相关.
- 在糖尿病患者中,测试阳性心痛的发病率在两性之间相似 (女性9.9/100人年,男性9.3/100人年).
结论:
- 稳定性心痛在女性和男性中发生的频率相似.
- 在女性中,稳定性心痛与与一般女性人口相比,冠状动脉死亡率升高有关.
- 稳定性心痛女性的特定子组表现出与男性相同的严重预后结果.
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