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Updated: Jul 12, 2026

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay
08:56

In Situ Detection of Ribonucleoprotein Complex Assembly in the C. elegans Germline using Proximity Ligation Assay

Published on: May 5, 2020

普罗利尔异构酶Pin1调节了粉样蛋白前体蛋白加工和粉样β生产

Lucia Pastorino1, Anyang Sun, Pei-Jung Lu

  • 1Cancer Biology Program, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts 02215, USA.

Nature
|March 24, 2006
PubMed
概括

Pin1 prolyl异构酶调节了粉样蛋白前体蛋白 (APP) 的加工和粉样β (Abeta) 的产生. Pin1放松调节增加了有毒的Abeta42,在阿尔茨海默病中将tau和Abeta病理联系起来.

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