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Updated: Jul 16, 2026

Intracellular Refolding Assay
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Published on: January 24, 2012

通过对基质和Hsp70的顺序 ubiquitination进行CHIP介导的应力恢复

Shu-Bing Qian1, Holly McDonough, Frank Boellmann

  • 1Carolina Cardiovascular Biology Center, School of Medicine, University of North Carolina, Chapel Hill, North Carolina 27599, USA.

Nature
|March 24, 2006
PubMed
概括

Hsp70结合蛋白 (CHIP) 的碳氧末端调节了热冲击蛋白70 (Hsp70) 的水平. CHIP在压力期间增强Hsp70并促进其在恢复期间的降解,保持细胞蛋白折叠恒温.

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