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妇女的左心室喷射率比男性高,无论左心室体积的差异如何:达拉斯心脏研究
Anne K Chung1, Sandeep R Das, David Leonard
1Donald W. Reynolds Cardiovascular Clinical Research Center, Division of Cardiology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390-9047, USA.
Circulation
|March 29, 2006
概括
女性的左心室喷射率 (LVEF) 比男性高. 这项研究确定了特定于性别的LVEF值,为男性和女性定义了较低的极限,以改善心脏健康评估.
科学领域:
- 心脏病学 心脏病学
- 心血管成像 - 心血管成像
- 人口健康 人口健康
背景情况:
- 临床实践经常使用对男性和女性均的左心室喷射率 (LVEF) 值.
- 关于LVEF的系统性基于性别的差异存在不确定性.
- 对其他心脏特征而言,性别特异性标准是常见的,但对于LVEF而言,历史上并非如此.
研究的目的:
- 为了比较女性和男性的左心室喷射分数 (LVEF).
- 为了确定性别是否影响LVEF,独立于其他因素.
- 建立特定于性别的值来定义低LVEF.
主要方法:
- 心脏磁共振成像 (CMR) 用于基于人口的样本.
- 左心室喷射分数 (LVEF) 在1435名30-65岁的女性和1183名男性之间进行了比较.
- 多变量分析评估了性别与中风体积的关联,控制了终端透气体积 (EDV) 和其他混因素.
主要成果:
- 与男性 (70%) 相比,女性的LVEF中位数 (75%) 较高 (P<0.001).
- 在女性中,左心室末端透缩体积 (EDV) 和指数为身体表面积的末端透缩体积较小.
- 性别仍然是中风体积的重要独立预测因素.
- 确定了低LVEF的特定性别值:女性低于61%,男性低于55%.
结论:
- 在一般人群中,女性的LVEF比男性高.
- 这种差异归因于女性在给定的终端透缩体积 (EDV) 中的较高中风体积.
- 这些发现支持在临床实践中需要性别特定的LVEF值.
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