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Updated: Jun 23, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
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Published on: April 13, 2015

通过抑制INK4/ARF位的Cdc6的致癌活性

Susana Gonzalez1, Peter Klatt, Sonia Delgado

  • 1Tumor Suppression Group, Spanish National Cancer Research Center (CNIO), E-28029 Madrid, Spain.

Nature
|March 31, 2006
PubMed
概括

过度表达的Cdc6通过形成异色素蛋白来抑制INK4/ARF瘤抑制位,促进癌症的发展. 这种机制涉及RD ((INK4/ARF) 调节元件,并将Cdc6与细胞永生和转化联系起来.

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