在心肺复苏期间由上腺素引起的肺通风/ perfusion 缺陷
W Tang1, M H Weil, R J Gazmuri
1Department of Medicine, University of Health Sciences, Chicago Medical School, IL 60064.
Circulation
|November 1, 1991
概括
通过改变肺血流,上腺素会在复苏期间损害二氧化碳的分泌. 这种效应在甲索中没有出现,需要更多的除冲击才能恢复自发循环.
科学领域:
- 心肺复苏是心肺复苏的方法之一.
- 身体生理学 身体生理学
背景情况:
- 在复苏期间,上腺素对二氧化碳分泌的影响是一个关键问题.
- 在动物心脏骤停模型中研究这一现象提供了宝贵的见解.
研究的目的:
- 为了研究上腺素在复苏期间对肺部二氧化碳分泌的影响.
- 为了在动物心脏骤停模型中比较上腺素与甲索胺和安慰剂的影响.
主要方法:
- 15只斯普拉格-道利大鼠经历了心脏骤停和机械呼吸.
- 测量了上腺素,甲胺和液安慰剂对冠状动脉 perfusion 压力和血液气体的影响.
- 记录了恢复自发循环所需的胸外逆震.
主要成果:
- 上腺素和甲索胺增加了冠状动脉 perfusion 压力;盐水没有.
- 上腺素显著降低了潮末的PCO2,PaO2,并增加了PaCO2,这表明死亡空间通风和肺动脉静脉混合的增加.
- 没有观察到这种变化与metoxamine或安慰剂.
结论:
- 上腺素在心肺复苏过程中引起呼吸/输液异常,这是由于肺血流的再分配.
- 这些V/Q变化可能会导致与上腺素观察到的除需求增加.
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