卡波西的肉瘤相关的疹病毒融合入口受体:囊载体xCT
Johnan A R Kaleeba1, Edward A Berger
1Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health, Bethesda, MD 20892, USA.
Science (New York, N.Y.)
|April 1, 2006
概括
卡波西卡波西 (Kaposi Kaposi) 是一个
科学领域:
- 病毒学 病毒学
- 细胞生物学 细胞生物学
- 分子生物学分子生物学
背景情况:
- 卡波西肉瘤相关的疹病毒 (KSHV) 导致卡波西肉瘤和淋巴增殖性疾病,特别是在艾滋病毒/艾滋病患者中.
- 了解KSHV进入机制对于开发向疗法至关重要.
研究的目的:
- 为了识别介导KSHV诱导的细胞融合和病毒进入的细胞受体.
- 调查已识别的受体在KSHV目标细胞允许性中的作用.
主要方法:
- 使用功能补充DNA (cDNA) 选择来识别KSHV受体.
- 用重组受体表达和抗体阻断试验来确认其功能.
- 进行了受体表达 (mRNA和蛋白质) 和细胞允许性之间的相关性分析.
主要成果:
- 氨酸/谷氨酸交换载体xCT被确定为KSHV受体.
- xCT表达使得不允许的细胞易受KSHV的融合和进入.
- 反xCT抗体抑制了KSHV的融合和进入允许细胞.
- 内源性xCT表达水平与KSHV目标细胞的容许性直接相关.
结论:
- 该xCT载体是KSHV细胞融合和进入的关键媒介.
- xCT对于KSHV目标细胞的容许性至关重要.
- 向xCT可能提供一种新的治疗策略来对抗KSHV感染.
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