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Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Human Virome01:26

Human Virome

The human body harbors a vast and diverse viral community known as the human virome. The virome includes bacteriophages that infect bacteria, and eukaryotic viruses that infect human cells. Transient dietary and environmental viruses also contribute to this dynamic ecosystem. Estimates suggest the human body may contain on the order of 10¹³ viral particles, though abundance varies widely by body site and detection method.Comprehensive characterization of the virome has become possible only with...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...

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Updated: Jul 18, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

人类癌症中的病毒.

H zur Hausen1

  • 1Deutsches Krebsforschungszentrum, Heidelberg, Germany.

Science (New York, N.Y.)
|November 22, 1991
PubMed
概括

病毒是人类癌症的重要原因,特别是宫癌和肝癌,是继烟草之后的第二大危险因素. 病毒感染可以通过各种机制导致瘤的发展,包括直接的coprotein生产或间接的免疫抑制.

科学领域:

  • 在瘤学瘤学.
  • 病毒学 病毒学
  • 癌症研究 癌症研究

背景情况:

  • 病毒通过多种机制与人类瘤的发展有关.
  • 机制包括间接的免疫抑制或直接的瘤原蛋白生产.
  • 病毒DNA整合可以改变宿主细胞蛋白质表达.

研究的目的:

  • 阐明病毒感染在人类癌症发展中的作用.
  • 为了确定与癌症发病率相关的关键病毒.
  • 了解病毒相关癌症对全球癌症负担的贡献.

主要方法:

  • 对病毒相关癌症的实验和流行病学数据的审查.
  • 与特定的人类病毒相关的癌症发病率的分析.
  • 检查有助于瘤发生的病毒机制.

主要成果:

  • 人类乳头瘤病毒,乙型肝炎病毒,爱斯坦-巴尔病毒和人类T细胞白血病-淋巴瘤病毒与全球约15%的癌症有关.
  • 子宫癌和肝细胞癌约占与病毒有关的癌症的80%.
  • 病毒被确定为人类癌症的第二大风险因素,仅次于烟草使用.

结论:

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Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
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Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

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Last Updated: Jul 18, 2026

Ex Vivo Infection of Live Tissue with Oncolytic Viruses
12:08

Ex Vivo Infection of Live Tissue with Oncolytic Viruses

Published on: June 25, 2011

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line
08:07

Differentiation of the SH-SY5Y Human Neuroblastoma Cell Line

Published on: February 17, 2016

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture
11:14

Ex Vivo Infection of Human Lymphoid Tissue and Female Genital Mucosa with Human Immunodeficiency Virus 1 and Histoculture

Published on: October 12, 2018

  • 病毒在特定的人类癌症的发展中起着关键的致病作用.
  • 宫癌和肝癌是全球病毒相关恶性瘤负担的主要贡献者.
  • 病毒是人类癌症发展的重要,二级风险因素.