相关实验视频
Updated: May 5, 2026

07:18
Live Imaging and Analysis of Muscle Contractions in Drosophila Embryo
Published on: July 9, 2019
5.4K
类型ID非传统的肌肉素控制了Drosophila的左右不对称性
Pauline Spéder1, Géza Adám, Stéphane Noselli
1Institute of Signalling, Developmental Biology & Cancer, UMR6543-CNRS, University of Nice Sophia-Antipolis, Parc Valrose, 06108 Nice Cedex 2, France.
Nature
|April 7, 2006
概括
科学家们确定了Myo31DF基因对于确定果左右身体轴方向至关重要. 在Myo31DF中发生的突变导致 situs inversus,扭转了生殖器的正常右侧循环,并揭示了它在手性决定中的作用.
科学领域:
- 发展生物学 发展生物学
- 遗传学 是一个遗传学.
- 分子生物学分子生物学
背景情况:
- 左右对称性破坏对于组织身体计划至关重要,导致两极分化的形态和器官功能.
- 左右轴方向 (位置选择) 的分子决定因素在很大程度上是未知的.
- 导致 situs inversus 的突变是理解手性机制的关键,但很少见.
研究的目的:
- 为了确定控制Drosophila中左右轴决定的新型基因.
- 阐明在模型生物体中选择网站的基础分子机制.
主要方法:
- 鉴定和描述Drosophila中的一个独特的网站反向位点.
- 基因马赛克分析以确定左右组织者和功能域.
- 对基因表达模式和蛋白质相互作用的分析.
主要成果:
- 保存类型的ID非传统肌肉蛋白31DF基因 (Myo31DF) 被确定为Drosophila.在Drosophila.在Drosophila.在Drosophila.在Drosophila.在Drosophila.在Drosophila.在Drosophila.在Drosophila.在Drosophila.
- Myo31DF突变逆转了成年生殖器的右侧循环,这是一个关键的左右标记.
- 基因分析确定生殖器盘的A8段是左右组织者,Myo31DF指导右侧发育并抑制左侧默认.
结论:
- Myo31DF作为一个具有基于actin的运动活性的右侧基因,控制Drosophila的网站选择.
- Myo31DF与β-catenin的相互作用和同位化表明通过粘附结通过网站确定的一种保存机制,类似于小鼠逆转.
相关概念视频
Position-effect Variegation
5.6K
In 1928, a German botanist Emil Heitz observed the moss nuclei with a DNA binding dye. He observed that while some chromatin regions decondense and spread out in the interphase nucleus, others do not. He termed them euchromatin and heterochromatin, respectively. He proposed that the heterochromatin regions reflect a functionally inactive state of the genome. It was later confirmed that heterochromatin is transcriptionally repressed, and euchromatin is transcriptionally active chromatin.
5.6K
Overview of Myosin Structure and Function
6.4K
Myosins are a family of molecular motor proteins, first identified in the skeletal muscles, where they are responsible for muscle contraction. Along with their role in muscle contraction, these proteins also play a role in the intracellular transport of molecules and vesicles. There are twenty-four classes of myosins based on their domain sequence and organization. Of the twenty-four, six classes (Myosin I, Myosin II, Myosin V, Myosin VI, Myosin VII, and Myosin X) have been well...
6.4K
The Ratio of X Chromosome to Autosomes
11.5K
In most organisms, sex is determined by the ratio of X and Y chromosomes. However, in some organisms, such as Drosophila and C.elegans, sex is determined by the ratio of the number of X chromosomes to the number of sets of autosomes. The Y chromosome in Drosophila is active but does not determine sex. It contains genes responsible for the production of sperms in adult flies.
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
Normal male Drosophila has a ratio of one X chromosome to two sets of autosomes. In contrast, normal female...
11.5K
Role of Myosin in Cell Migration
2.8K
Myosins are multimeric motor proteins involved in various cellular processes such as migration, adhesion, and proliferation. Myosin II is the most common type in animal cells, which binds and cross-links actin filaments.
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
Myosin II is a hexamer comprising two heavy chains with globular heads and coiled-coil tails, two regulatory light chains, and two essential light chains. The ATPase sites on the myosin heads hydrolyze ATP, and the released phosphate generates the force for contraction....
2.8K

