输血后的微循环功能障碍,包括高卡利米,低热,心肌的溶液和血液再输血. 腺氨酸的作用
M W Keller1, L Geddes, W Spotnitz
1Department of Medicine, University of Virginia Health Sciences Center, University of Virginia, Charlottesville 22908.
Circulation
|December 1, 1991
概括
低温,高血性心脏解决方案可以在心脏手术再注射期间损害微血管. 氨酸可以通过扩大血管和减少中性粒细胞的积累来部分缓解这种损伤.
科学领域:
- 心血管外科心血管外科
- 血管生物学 血管生物学
- 微循环研究 微循环研究
背景情况:
- 心脏的解决方案对于心脏手术期间心肌脏的保存至关重要.
- 然而,再注射损伤和心脏引起的内皮功能障碍可能会损害术后心脏功能.
- 心脏解决方案对冠状动脉和静脉移植的影响已知,但对微血管系统的影响不太清楚.
研究的目的:
- 为了研究输液后的微血管损伤,用高卡利米,晶类心脏的溶液和随后的血液再输液.
- 评估腺和白蛋白在减轻这种损伤方面的潜在保护作用.
主要方法:
- 一个仓鼠的肌肉模型被用来观察心肌的溶液 perfusion 和血液 reperfusion 期间的微血管变化.
- 静脉内显微镜评估了动脉的直径,毛细血管 perfusion 密度和中性粒细胞的积累.
- 测量了骨髓氧化酶水平,以量化血管外中性粒细胞透.
主要成果:
- 晶体心溶液 perfusion 导致动脉血管收缩和毛细血管 perfusion 的降低.
- 在静脉内皮和外血管上观察到中性粒细胞积累的显著增加.
- 将腺和白添加到心脏症溶液中,并在再注射过程中给予腺,导致动脉血管扩张和中性粒细胞积累减少,尽管毛细血管 perfusion 仍然减少.
结论:
- 低温,高卡利米,晶体性心脏损伤溶液诱导微血管损伤,其特点是血液流量减少和中性粒细胞积累增加.
- 氨酸通过促进血管扩张和减少中性粒细胞透来部分减轻这种损伤的潜力.
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