在人类和黑猩猩中,苦味敏感性的独立演变
Stephen Wooding1, Bernd Bufe, Christina Grassi
1Department of Human Genetics, University of Utah, 15 North 2030 East, Salt Lake City, Utah 84112-5330, USA. swooding@genetics.utah.edu
Nature
|April 14, 2006
概括
人类和黑猩猩对苦味化合物甲基胺 (PTC) 具有不同的敏感性,这是由于TAS2R38受体变异的独立进化. 味觉感知中的这种遗传变异在每个物种中分别出现.
科学领域:
- 进化生物学是进化的生物学.
- 遗传学 是一个遗传学.
- 感官科学是一种感官科学.
背景情况:
- 人类和黑猩猩对基胺 (PTC) 的可变味觉敏感性以前被归因于共享的平衡多态性.
- 人类PTC味道变异主要与TAS2R38位点的两个共同基因有关,编码不同的苦味受体变异.
研究的目的:
- 为了研究PTC味道敏感度变化的遗传基础,在黑猩猩.
- 为了确定PTC味道变化的基础分子机制是否在人类和黑猩猩之间共享.
主要方法:
- 在黑猩猩中TAS2R38位点的基因定型.
- 黑猩猩TAS2R38受体变体的体外功能测试.
- 在黑猩猩中,TAS2R38基因型与体内PTC品尝者身份的关联测试.
主要成果:
- 黑猩猩拥有两种共同的TAS2R38等位基因控制PTC敏感性,但这些等位基因与人类发现的不同.
- 黑猩猩TAS2R38基因的特定突变导致了对PTC不响应的截断受体变体.
- 黑猩猩TAS2R38基因型准确地预测了PTC品尝者状态,证实了它在味觉感知中的作用.
结论:
- PTC味道变化的分子基础在人类和黑猩猩中独立演变.
- 以前关于大猿PTC口味变化的共同遗传基础的假设是不正确的.
- 融合进化解释了不同物种中不同的TAS2R38等位基因介导的可变苦味感知的类似现象.
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