在真空空间中,Toxoplasma gondii将哺乳动物宿主中的溶解体隔离起来
Isabelle Coppens1, Joe Dan Dunn, Julia D Romano
1Department of Molecular Microbiology and Immunology, Johns Hopkins University Bloomberg School of Public Health, 615 N. Wolfe Street, Baltimore, MD 21205, USA. icoppens@jhsph.edu
Cell
|April 25, 2006
概括
毒素菌积极招募宿主细胞的微管,以吸引内溶酶体进入其保护真空中. 这一过程为寄生虫生长提供营养,并将宿主器官绑定起来.
科学领域:
- 细胞生物学 细胞生物学
- 寄生虫学的寄生虫学
- 分子生物学分子生物学
背景情况:
- 毒素菌是一种有义务的细胞内寄生虫,在宿主衍生的真空体内复制.
- 寄生虫的快速生长需要有效地从宿主细胞获取营养.
研究的目的:
- 为了阐明Toxoplasma gondii从宿主内溶体系统中获取营养的机制.
- 研究宿主细胞基础设施在支持寄生虫细胞内生存中的作用.
主要方法:
- 活细胞成像用于观察器官贩运.
- 免疫光显微镜可视化蛋白质定位.
- 寄生虫和宿主因子的遗传操纵.
主要成果:
- 淋巴菌积极招募宿主微管到寄生虫的真空管 (PV).
- 主体内溶酶体被选择性地吸引并通过微管体依赖的诱导通过微管体依赖的诱导进入PV.
- 寄生虫蛋白GRA7覆盖管状管道,在PV内隔离宿主器官.
结论:
- T. gondii采用一种独特的机制来劫持宿主内溶体贩运以获取营养.
- 光伏膜形成专门的管道,用于单向的有机细胞运输和封存.
- 这一过程为寄生虫提供了对宿主衍生的营养物质的集中访问,这些营养物质对于复制至关重要.
相关概念视频
Symbiosis
27.8K
Symbiotic relationships are long-term, close interactions between individuals of different species that affect the distribution and abundance of those species. When a relationship is beneficial to both species, this is called mutualism. When the relationship is beneficial to one species but neither beneficial nor harmful to the other species, this is called commensalism. When one organism is harmed to benefit another, the relationship is known as parasitism. These types of relationships often...
27.8K
Lysosomes
16.0K
Lysosomes are membrane-enclosed spherical sacs derived from the Golgi apparatus. The most important function of the lysosome is degrading macromolecules and biological polymers that are released during membrane trafficking events such as the secretory, endocytic, autophagic, and phagocytic pathways. The degradation is carried out by several hydrolytic enzymes active in an acidic environment of the lysosomal lumen. These acid hydrolases are involved in cellular processes such as cell signaling,...
16.0K
Lysosomal Hydrolases
3.6K
Lysosomes are the site for the degradation of macromolecules and biological polymers released during membrane trafficking events such as secretory, endocytic, autophagic, and phagocytic pathways. The membrane-enclosed area of the lysosome, called the lumen, contains hydrolytic enzymes active in an acidic environment. These acid hydrolases are functional at a pH between 4.5 and 5 and are involved in cellular processes such as cell signaling, energy metabolism, restoration of the plasma membrane,...
3.6K
Fungal Phylum Microsporidia
787
Microsporidia are a group of obligate intracellular fungi that were initially classified as protists but were later reclassified based on phylogenetic, molecular, and structural evidence linking them to the Chytridiomycota. These unicellular, non-motile organisms are highly specialized parasites that infect a wide range of animal hosts, including humans. They have evolved extensive genomic and metabolic reductions, making them highly dependent on their hosts for survival.Morphology and Genomic...
787
Diversity of Protists II
2.3K
Alveolates are a group of organisms recognized by the presence of alveoli, which are cytoplasmic sacs located beneath the cell membrane. While their function remains uncertain, alveoli may help regulate water balance by controlling how much water enters and leaves the cell. In dinoflagellates, these structures may serve as armor plates. There are three major types of alveolates: ciliates, which move using cilia; dinoflagellates, which use flagella for movement; and apicomplexans, which are...
2.3K
Microbial Interactions: Parasitism
121
Parasitism is a form of microbial interaction in which parasitic microbes exploit a host organism for nutrients and shelter, often at the host's expense. Unlike mutualistic relationships, where both organisms benefit, parasitism benefits only the parasite and harms the host.Classification of ParasitesMicrobial parasites are broadly classified based on their location relative to the host.Ectoparasites remain on the host’s surface, such as the skin or outer tissues, drawing nutrients...
121


