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相关概念视频

Ultra-High-Speed Western Blot using Immunoreaction Enhancing Technology05:59

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An ultra-high-speed western blotting technique is developed by improving the kinetics of antigen-antibody binding through cyclic draining and replenishing (CDR) technology in conjunction with an immunoreaction enhancing...
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In this protocol, porcine specific primers were designed, plasmids-containing porcine specific DNA fragments were constructed, and standard curves for quantitation were established. Using species-specific primers, cpsDNA was quantified by qPCR in pig-to-mouse cell transplantation models and pig-to-monkey artery patch transplantation...
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This protocol describes a method to track individual brain-aging trajectories through a brain donation program and proper characterization of brains. Brain donors are involved in a long-term longitudinal study including serial multi-dimensional assessments. The protocol contains a detailed description of brain processing and an accurate diagnostic...
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We outline a methodology for the processing of whole blood to obtain a variety of components for further analysis. We have optimized a streamlined protocol that enables rapid, high-throughput simultaneous processing of whole blood samples in a non-clinical...
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Biomarkers are directly-measured biological indicators of disease or health. In population and social sciences, biomarkers need to be easy to obtain, transport, and analyze. Dried Blood Spot (DBS) collection meets this need, can be collected in the field with high response rates and analyzed for a variety of...
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We are describing a new method of isolating genomic DNA from whole blood collected for plasma/serology. After plasma collection, the compacted blood is usually discarded. Our novel method represents a significant improvement over existing methods and makes DNA and plasma available from a single collection, without requesting additional...
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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains
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在心脏节拍过程中心力衰竭.

Michael O Sweeney1, Anne S Hellkamp

  • 1Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. mosweeney@partners.org

Circulation
|April 26, 2006
PubMed
概括

右心室角节奏增加了心力衰竭住院的风险,特别是在低射出率或心力衰竭的患者中. 管理节奏模式和QRS持续时间对于降低这种风险至关重要.

科学领域:

  • 心脏病学 心脏病学
  • 电子生理学 电子生理学
  • 医疗器械 医疗器械

背景情况:

  • 右心室角 (RVA) 节奏可以导致异常的左心室收缩,增大和功能减弱.
  • 室腔脱同步从RVA节奏与心力衰竭住院 (HFH) 的风险增加有关.

研究的目的:

  • 在接受双室 (DDDR) 与心室 (VVIR) 节奏的患者中确定HFH的预测因子.
  • 分析基线特征和节奏参数对高风险的影响.

主要方法:

  • 模式选择试验分析了2010名患者6年,比较DDDR和VVIR节奏.
  • 考克斯的比例危险模型被用来确定HFH的预测因素,包括纽约心脏协会 (NYHA) 的类别,心力衰竭,心 (AV) 阻塞,心肌梗塞 (MI),累积百分比心室节奏 (Cum%VP) 和QRS持续时间 (QRSd).

主要成果:

  • 基线NYHA类,心力衰竭,AV阻塞和MI预测HFH.
  • 植入后预测因素包括高的VVIR Cum%VP (>80%),特定的DDDR/VVIR Cum%VP值,以及节奏与自发QRS持续时间.
  • 低射出分数 (EF) 和更长的QRSd (特别是在节奏时) 是显著的预测因素,正常EF患者的风险增加更快.

结论:

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  • HFH风险受到患者基质 (例如,心房动,心力衰竭,EF) 和步调参数 (例如,QRSd,Cum%VP,步调模式) 之间的相互作用的影响.
  • 有效地管理RVA节奏对于减轻HFH风险至关重要,特别是在低EF和现有心力衰竭的脆弱患者群体中.