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巨细胞金属弹性酶加速了转基因子中动脉样硬化的进展

Jingyan Liang¹, Enqi Liu, Ying Yu

¹Department of Pathology, Institute of Basic Medical Sciences, University of Tsukuba, Tsukuba, Japan.

|April 26, 2006

概括

巨细胞金属弹性酶 (MMP-12) 的过度表达加速了子中的动脉样硬化发展. 这表明MMP-12在促进这种心血管疾病的进展方面发挥着关键作用.

科学领域:

心血管研究研究心血管研究
生物医学科学生物医学科学
病理学病理学病理学

背景情况:

在动脉样硬化病变中,巨金属稳酶 (矩阵金属蛋白酶[MMP]-12) 的水平升高.
MMP-12在动脉样硬化开始和进展中的作用尚不清楚.

研究的目的:

研究MMP-12在动脉样硬化中的病理作用.
为了比较MMP-12转基因 (Tg) 子与非Tg littermates的动脉样硬化发展.

主要方法:

给MMP-12Tg和非Tg子食富含胆固醇的饮食以诱导高胆固醇血症.
在不同持续时间和高胆固醇血症水平下评估了动脉样硬化进展.
组织学分析检查了病变的大小,质量,巨细胞透和弹性膜完整性.

主要成果:

在较低的高胆固醇血清水平下,没有观察到动脉样硬化的显著差异.
在较长时间的高胆固醇血下,Tg子在大动脉和冠状动脉中表现出更广泛的动脉样硬化.
在Tg子病变中,巨细胞透率增加,弹性膜被破坏,以及动脉瘤状的形成.

结论:

过度表达MMP-12加速了子中的动脉样硬化.
巨细胞衍生的MMP-12与动脉样硬化的进展有关.

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