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In Vitro Differentiation of Naive CD4+ T Cells into Pathogenic Th17 Cells in Mouse
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产生致病效应体TH17和调节性T细胞的相互发育途径

Estelle Bettelli1, Yijun Carrier, Wenda Gao

  • 1Center for Neurologic Diseases, Beth Israel Hospital, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA.

Nature
|May 2, 2006
PubMed
概括

互白素-6 (IL-6) 阻断了调节性T细胞 (Treg) 的发展,同时促进了致病性T助手17 (Th17) 细胞. 这种IL-6活动创造了一个平衡,有利于自身免疫组织损伤而不是其抑制.

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