相关实验视频
Updated: Jul 16, 2026
09:22
Mouse Pneumonectomy Model of Compensatory Lung Growth
Published on: December 17, 2014
支气管肺部发育不良症
John P Kinsella1, Anne Greenough, Steven H Abman
1Department of Paediatrics, University of Colorado School of Medicine, Denver, USA. John.kinsella@uchsc.edu
Lancet (London, England)
|May 3, 2006
概括
支气管肺功能障碍症 (BPD) 是一种慢性肺部疾病,影响早产婴儿,增加住院再接收和长期呼吸道问题. 研究正在探索新的治疗方法,以减少肺损伤,并改善患病婴儿的肺生长.
科学领域:
- 新生儿科学 新生儿科学
- 儿科肺病学 儿科肺病学
- 慢性肺部疾病 慢性肺部疾病
背景情况:
- 支气管肺功能障碍症 (BPD) 是早产婴儿患病和死亡的一个重要原因.
- 极度早产婴儿的生存率增加导致BPD病例的增加.
- 由于频繁的住院再诊和持续的呼吸道症状到青春期,BPD对医疗保健资源造成了巨大的负担.
研究的目的:
- 为了解决BPD的不断变化的理解,包括"新的BPD",其特点是长期依赖氧气而没有严重的急性呼吸困扰.
- 调查产后肺生长障碍作为"新型BPD"的原因的可能性.
- 探索这些婴儿的追赶肺生长的未知因素,特别是关于产后皮质类固醇的使用.
主要方法:
- 对BPD病原和临床结果的当前文献的综述.
- 分析BPD定义和临床表现的变化.
- 识别有关肺生长和治疗干预措施的知识差距.
主要成果:
- BPD的定义已经演变,在没有严重急性呼吸困扰的婴儿中出现了"新的BPD",可能与肺生长受损有关.
- 患有BPD的婴儿经历了显著的长期呼吸系统问题,需要经常使用医疗保健.
- 产后皮质类固醇对BPD追赶肺生长的疗效目前尚不清楚.
结论:
- 支气管肺功能障碍在新生儿护理中是一个持续的挑战,其患病率越来越高.
- 需要进一步的研究,以了解"新型BPD"中肺生长受损的机制.
- 开发安全有效的预防疗法和改善肺生长的治疗方法是未来研究的关键领域.
更多相关视频
相关概念视频
01:05Breathing
The process of breathing, inhaling and exhaling, involves the coordinated movement of the chest wall, the lungs, and the muscles that move them. Two muscle groups with important roles in breathing are the diaphragm, located directly below the lungs, and the intercostal muscles, which lie between the ribs. When the diaphragm contracts, it moves downward, increasing the volume of the thoracic cavity and creating more room for the lungs to expand. When the intercostal muscles contract, the ribs...
01:17Pulmonary Cycle: Exhalation
In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
01:21Acute Respiratory Failure-II
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
01:23Chronic Obstructive Pulmonary Disease II: Emphysema
Emphysema, a major phenotype of chronic obstructive pulmonary disease (COPD), is characterized by irreversible destruction of alveolar walls and permanent enlargement of distal airspaces. Unlike chronic bronchitis, which primarily affects the airways, emphysema predominantly involves the lung parenchyma, where structural damage leads to airflow limitation.PathophysiologyIt most commonly results from prolonged exposure to cigarette smoke and other toxic gases, particularly cigarette smoke.
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...