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Updated: Jul 15, 2026

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors
10:33

Development of Inhibitors of Protein-protein Interactions through REPLACE: Application to the Design and Development Non-ATP Competitive CDK Inhibitors

Published on: October 26, 2015

寻找依赖于环林的激酶抑制剂,使用一种新的消除应对的变异

Roger J Griffin1, Andrew Henderson, Nicola J Curtin

  • 1Northern Institute for Cancer Research, School of Natural Sciences-Chemistry, Bedson Building, University of Newcastle, Newcastle upon Tyne, UK.

Journal of the American Chemical Society
|May 4, 2006
PubMed
概括

研究人员开发了新的β-氨基乙硫作为强大的循环素依赖性激酶CDK2抑制剂. 最有效的化合物,IC50为45nM,对药物化学应用有很大的希望.

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相关概念视频

Enzyme Inhibition01:30

Enzyme Inhibition

Inhibitors are molecules that reduce enzyme activity by binding to the enzyme. In a normally functioning cell, enzymes are regulated by a variety of inhibitors. Drugs and other toxins can also inhibit enzymes. Some inhibitors bind to the enzyme’s active site, while others inhibit enzymatic activity by binding to other sites on the protein structure.