核受体联合激活器的不断扩大的宇宙
David M Lonard1, Bert W O'Malley
1Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.
Cell
|May 9, 2006
概括
在由核受体调节的基因表达中,超过200个协活性剂至关重要. 这些蛋白质集成了类固醇激素信号,与癌症等疾病有关.
科学领域:
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
- 内分泌学 在内分泌学.
背景情况:
- 核受体是基因表达的关键调节者.
- 共激活剂是核受体功能必不可少的合作伙伴.
- 共激活剂活性失调与包括癌症在内的各种疾病有关.
研究的目的:
- 突出共同激活剂在核受体介导基因表达中的中心作用.
- 强调协同激活剂作为类激素信号传递的整合剂的功能.
- 为了强调协同激活剂在疾病发病过程中的影响.
主要方法:
- 这项研究是对现有文献的综述.
- 蛋白质与蛋白质相互作用的分析.
- 基因表达测试. 基因表达测试.
主要成果:
- 已经确定了大约200种联合激活剂.
- 联合激活剂是各种各样的蛋白质组.
- 联合激活剂调解来自类固醇激素的信号.
结论:
- 共激活剂对于核受体的功能是不可或缺的.
- 协作激活器作为关键信号集成器.
- 共激活器功能障碍与癌症和其他疾病有关.
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