持续的术后疼痛:风险因素和预防
Henrik Kehlet1, Troels S Jensen, Clifford J Woolf
1Section of Surgical Pathophysiology 4074, Juliane Marie Centre, Rigshospitalet, 2100 Copenhagen, Denmark. henrik.kehlet@rh.dk
Lancet (London, England)
|May 16, 2006
概括
持续的术后疼痛影响了手术后10-50%的患者. 早期,积极的疼痛管理和神经节约技术可以降低慢性神经病痛的风险.
科学领域:
- 疼痛医学 医学 疼痛医学
- 手术研究的研究.
- 神经学 神经学
背景情况:
- 持续的术后疼痛影响10-50%的人在常见的手术后.
- 慢性疼痛在2-10%的患者中可能是严重的,代表了显著的临床问题.
- 创伤性神经病痛是长期术后疼痛的主要原因.
研究的目的:
- 概述识别患有持续术后疼痛风险的患者的策略.
- 探索慢性术后疼痛的预防和治疗机会.
- 为了强调治疗手术后神经病痛的重要性.
主要方法:
- 审查神经病痛的分子机制.
- 分析急性疼痛强度与慢性疼痛发展之间的相关性.
- 研究遗传因素在慢性疼痛易感性中的作用.
主要成果:
- 减少神经损伤的手术技术对于预防至关重要.
- 早期和积极管理急性术后疼痛可能会降低持续疼痛的风险.
- 基于对神经病痛机制的理解,多模式药理干预措施显示出有前途.
结论:
- 持续的术后疼痛,特别是神经病痛,是主要的临床问题.
- 识别有风险的患者和实施预防策略至关重要.
- 需要进一步研究遗传因素和新的药理疗法.
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