随机临床试验,临床医生优先选择的治疗
1Biometric Research Branch, National Cancer Institute, Bethesda, Maryland 20892.
Lancet (London, England)
|January 19, 1991
概括
标准的随机临床试验可能不适合临床医生更喜欢特定治疗的情况. 一种替代方法表明,只有当有患者随机选择时,才会随机选择患者.
科学领域:
- 临床试验方法论 临床试验方法论
- 医学伦理 医学伦理
- 以患者为中心的护理
背景情况:
- 当临床医生有强烈的治疗偏好或对优越性的信念时,标准随机临床试验 (RCT) 可能是不理想的.
- 临床偏见可以影响传统RCT中的试验设计和患者结果.
研究的目的:
- 为临床医生治疗偏好情况提出替代试验设计.
- 确保患者分配与临床判断一致,当存在分歧时.
主要方法:
- 随机分配患者的治疗建议只有当临床分歧最好的选择出现.
- 然后将患者分配给支持分配治疗方案的临床医生.
主要成果:
- 这种修改后的方法解决了标准RCT可能由于临床医生的专业知识或偏好而不合适的场景.
- 它旨在将临床判断纳入随机化过程.
结论:
- 拟议的设计为提高临床试验在实践中的适用性提供了一个潜在的解决方案.
- 它试图平衡随机化与个性化的临床决策.
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