古巴预防状细胞病的预防计划
H Granda1, S Gispert, A Dorticós
1National Centre of Medical Genetics, Higher Institute of Medical Science, Havana, Cuba.
Lancet (London, England)
|January 19, 1991
概括
在古巴,古巴,古巴.
科学领域:
- 医学遗传学 医学遗传学
- 公共卫生 公共卫生
- 血液学 血液学 血液学
背景情况:
- 在古巴,状细胞基因携带者的比例因地区而异 (3-7%).
- 一个国家状细胞疾病控制计划于1983年启动.
- 该计划整合了教育,查,咨询和产前诊断.
研究的目的:
- 评估古巴全国状细胞疾病控制计划的有效性.
- 报告查结果和遗传咨询和产前诊断的影响.
主要方法:
- 全国范围内对孕妇和父亲进行血红蛋白异常的查.
- 对有风险的夫妇进行遗传咨询.
- 对于高风险怀孕的产前诊断.
- 基于产前诊断结果的妊娠终止.
主要成果:
- 查了806,935名孕妇,发现3.7%的血红蛋白异常.
- 测试了19686名父亲,发现了1268对有风险的夫妇.
- 在531个怀孕中进行了产前诊断,确认了98个受影响的胎儿 (SS或SC).
- 终止了72次怀孕,胎儿受到了影响.
结论:
- 古巴的状细胞疾病控制计划成功识别了有风险的夫妇和受影响的胎儿.
- 产前诊断和随后的妊娠终止显著影响了疾病患病率.
- 该计划展示了在不同人群中治疗状细胞疾病的可行模型.
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