Jove
Visualize
联系我们
JoVE
x logofacebook logolinkedin logoyoutube logo
关于 JoVE
概览领导团队博客JoVE 帮助中心
作者
出版流程编辑委员会范围与政策同行评审常见问题投稿
图书馆员
用户评价订阅访问资源图书馆顾问委员会常见问题
研究
JoVE JournalMethods CollectionsJoVE Encyclopedia of Experiments存档
教育
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab Manual教师资源中心教师网站
使用条款与条件
隐私政策
政策

相关概念视频

您也可能阅读

相关文章

通过共同作者、期刊和引用图与本文相关的文章。

排序
Same author

Evidence for the Collective Nature of Radial Flow in Pb+Pb Collisions with the ATLAS Detector.

Physical review letters·2026
Same author

Evidence for Longitudinally Polarized W Bosons in the Electroweak Production of Same-Sign W Boson Pairs in Association with Two Jets in pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Observation of tt[over ¯] Production in Pb+Pb Collisions at sqrt[s_{NN}]=5.02  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Dark Matter Produced in Association with a Dark Higgs Boson in the bb[over ¯] Final State Using pp Collisions at sqrt[s]=13  TeV with the ATLAS Detector.

Physical review letters·2025
Same author

Search for Magnetic Monopole Pair Production in Ultraperipheral Pb+Pb Collisions at sqrt[s_{NN}]=5.36  TeV with the ATLAS Detector at the LHC.

Physical review letters·2025
Same author

Simultaneous Unbinned Differential Cross-Section Measurement of Twenty-Four Z+jets Kinematic Observables with the ATLAS Detector.

Physical review letters·2025

相关实验视频

Updated: Jul 6, 2026

Measurement of γHV68 Infection in Mice
13:22

Measurement of γHV68 Infection in Mice

Published on: November 22, 2011

编程细胞死亡和Vbeta8+ CD4+ T 细胞的异常减少,在对黄金葡萄球菌 (Staphylococcus aureus) 肠毒素B耐受性小鼠中.

Y Kawabe1, A Ochi

  • 1Department of Immunology and Medical Genetics, University of Toronto, Ontario, Canada.

Nature
|January 17, 1991
PubMed
概括
此摘要是机器生成的。

通过克隆缺失可以诱导外围T细胞耐受性. 研究表明,在小鼠中暴露于金黄色葡萄球菌肠毒素B导致特定T细胞的减少,表明细胞死亡有助于耐受性.

更多相关视频

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

相关实验视频

Last Updated: Jul 6, 2026

Measurement of γHV68 Infection in Mice
13:22

Measurement of γHV68 Infection in Mice

Published on: November 22, 2011

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection
09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model
06:02

A Contemporary Warming/Restraining Device for Efficient Tail Vein Injections in a Murine Fungal Sepsis Model

Published on: November 6, 2020

科学领域:

  • 免疫学 免疫学 免疫学
  • T细胞生物学T细胞生物学
  • 周边的容忍度 周边的容忍度

背景情况:

  • 像克隆删除和无活化这样的内部机制塑造了T细胞的耐受性.
  • 这些机制在外围T细胞对自我和外源抗原的耐受性中的作用尚不清楚.
  • 周围T细胞耐受性越来越多地与克隆性无能相关.

研究的目的:

  • 为了研究诱导外血型T细胞耐受性.
  • 确定删除机制是否有助于外围T细胞耐受性.

主要方法:

  • 在BALB/c小鼠中诱导对金黄色葡萄球菌肠毒素B (SEB) 的耐受性.
  • 对外围T细胞,特别是Vβ8.1,2+CD4+T细胞的分析,在euthymic和athymic小鼠中.
  • 评估基因组DNA碎片化作为细胞死亡的指标.

主要成果:

  • 耐受SEB的小鼠表现出Vβ8.1,2+ CD4+外围T细胞的显著减少.
  • 这种T细胞的减少与基因组DNA碎片化有关,这表明了亡.
  • 优和不优的小鼠都表现出这种删除机制.

结论:

  • 缺失机制有助于诱导T细胞耐受性在周围淋巴细胞.
  • 超性耐受性可以通过细胞死亡途径进行调解.
  • 周围T细胞的耐受性不仅仅取决于胸膜选择.