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系统性硬化症:基于假设的治疗策略.

Christina Charles1, Philip Clements, Daniel E Furst

  • 1Department of Medicine, Division of Rheumatology, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095-1670, USA.

Lancet (London, England)
|May 23, 2006
PubMed
概括

针对系统性硬化症的血管并发症的治疗显示出成功,改善了生活质量和生存率. 虽然抗纤维化策略仍在发展,但新的方法为这种复杂的自身免疫性疾病提供了未来的希望.

科学领域:

  • 类风湿病学 类风湿病学
  • 免疫学 免疫学 免疫学
  • 血管医学 血管医学

背景情况:

  • 系统性硬化症是一种复杂的自身免疫性疾病,其特点是血管损伤,纤维化和免疫系统异常.
  • 了解全身性硬化症的发病因子对于开发有效的治疗策略至关重要.

研究的目的:

  • 审查对照和随机对照试验,检查系统性硬化症的发病因子.
  • 评估目前和新兴治疗系统性硬化症的疗效.

主要方法:

  • 对受控试验和随机对照试验数据的系统审查.
  • 对血管并发症,纤维化和全身特征的治疗策略的分析.

主要成果:

  • 针对血管并发症的治疗方法,如脏危机和肺动脉高血压,已经取得了显著的成功.
  • 免疫抑制疗法,特别是环胺,显示出有效性,目前正在进行自身干细胞移植试验.
  • 到目前为止,直接的抗纤维化策略 (例如,博森坦,干扰素,放松剂) 取得了令人失望的结果.

结论:

  • 针对血管的治疗方法是系统性硬化症的疾病修饰化合物,改善患者的功能,生活质量和生存率.
  • 基于分子理解的新抗纤维化策略对未来的全身性硬化症治疗有希望.

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  • 同时治疗多种疾病特征是未来临床试验的考虑因素.