长期抑制震,通过慢性刺激腹中介质乳头核
A L Benabid1, P Pollak, C Gervason
1Department of Clinical and Biological Neurosciences, INSERM Preclinical Neurobiology U 318, Joseph Fourier University of Grenoble, France.
Lancet (London, England)
|February 16, 1991
概括
腹中中间核 (Vim) 的高频刺激有效地治疗了帕金森病中残疾震.
科学领域:
- 神经外科 神经外科
- 神经学 神经学
- 医疗器械 医疗器械
背景情况:
- 削弱震显著影响了帕金森病和基本震患者的生活质量.
- 对于耐火性震病例,可以考虑进行神经外科干预.
研究的目的:
- 评估腹中中间核 (Vim) 高频刺激的疗效,作为治疗残疾震的主要神经外科治疗方法.
- 为了比较Vim刺激与thalamotomy的结果,特别是双边治疗.
主要方法:
- 植入慢性刺激电极连接到Vim.中的脉冲发生器.
- 在休息时,保持姿势和动作/意图操纵时,使用加速度计评估震幅度.
- 该研究包括患有帕金森病和基本震的患者,其中一些患者先前接受了沙拉切除术或双边刺激.
主要成果:
- 88%的受刺激的沙拉米 (27个完全缓解,11个主要改善) 显示显著减轻震.
- 症状改善持续长达29个月 (平均随访时间为13个月).
- 副作用是轻微的,可以通过调整刺激参数来控制.
结论:
- 高频Vim刺激是一种高度有效的治疗残疾震的方法.
- 维姆刺激的可逆性和适应性比thalamotomy提供了优势,特别是在双边干预方面.
- 由于其安全性和有效性,Vim刺激是一种可取的神经外科选择.
相关概念视频
01:27Diencephalon: Thalamus and Information Relay
The thalamus, often called “the gateway to the cerebral cortex,” is vital in processing and directing sensory and motor signals throughout the brain. Almost all inputs destined for the cerebral cortex, except for olfactory signals, are relayed through the thalamus. The thalamus is a sophisticated relay station, channeling information from various brain regions to the cerebral cortex, as well as a filter, prioritizing certain signals over others based on current physiological states or needs.
01:22Indirect Motor Pathways
The indirect motor or extrapyramidal pathways originate in the brainstem, the lower portion of the brain that connects it to the spinal cord. They consist of several distinct tracts, each with specialized functions. The four main tracts of the indirect motor pathways are the vestibulospinal tract, the reticulospinal tract, the tectospinal tract, and the rubrospinal tract.
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...
The vestibulospinal tract originates in the vestibular nuclei of the brainstem. The vestibular system detects changes in...