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转变生长因子-β1对心房节导电修饰的影响,由注射到狗心脏的自主纤维细胞进行修饰.

T Jared Bunch1, Srijoy Mahapatra, G Keith Bruce

  • 1Division of Cardiovascular Disease, Department of Internal Medicine, Mayo Clinic, Rochester, MN 55902, USA.

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|May 24, 2006
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此摘要是机器生成的。

注射纤维细胞可以修改心房 (AV) 节点导电,作为心房 (AF) 的消化疗法的替代方案. 使用转化生长因子-β1 (TGF-β1) 的预处理显著增强了这种AV节点修饰.

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科学领域:

  • 心血管研究研究心血管研究
  • 再生医学是一种再生医学.
  • 电子生理学 电子生理学

背景情况:

  • 对心房动 (AF) 的心房 (AV) 结节切除是不可逆转的,需要永久的起器植入.
  • 研究用于AV节点调制的替代性,可逆方法对于AF管理至关重要.

研究的目的:

  • 评估自主纤维细胞在周节区域植入用于修改AV节点传导的疗效.
  • 确定用转化生长因子-β1 (TGF-β1) 的预处理是否增强纤维细胞的AV节点调节效应.

主要方法:

  • 自主纤维细胞从狗皮肤活检中培养出来.
  • 纤维细胞,TGF-β1或盐水被注射到狗的周围AV节点区域,使用电解剖绘图指导.
  • 在基线和4周后通过测量间隔 (AH,RR) 来评估AV节点功能.

主要成果:

  • 纤维细胞注射单独增加了正常鼻节律中的AH间隔和AF期间的RR间隔.
  • 与TGF-beta1同时使用纤维细胞导致AH间隔的显著增加,比单独使用纤维细胞更大.
  • 单独的TGF-β1并没有显著增加AH间隔,但增强了纤维细胞的作用.
  • 在4周的任何组中都没有观察到AV阻塞;标记的纤维细胞被确定.

结论:

  • 注射的纤维细胞可以在不引起AV阻塞的情况下实现AV节点修饰.
  • 用TGF-β1进行预处理可以显著增强纤维细胞对AV结节导电修饰的作用.
  • 这些发现表明一种潜在的治疗策略,可以在不需要心脏起器植入的情况下控制AF的快速心室率.