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Measurement of Lifespan in Drosophila melanogaster
Published on: January 7, 2013
婴儿期或成年期的贫困:哪一个对死亡风险更重要?
1Department of Epidemiology and Public Health, University College and Middlesex School of Medicine, UK.
Lancet (London, England)
|March 2, 1991
概括
早期生活条件可能不会直接影响成人心血管疾病. 社会经济因素,而不是早期生活事件,似乎解释了婴儿和成人死亡率之间的历史联系.
科学领域:
- 流行病学 流行病学
- 公共卫生 公共卫生
- 健康的社会决定因素
背景情况:
- 生态研究表明,早期生活因素会影响成人心血管和呼吸系统疾病.
- 在过去的婴儿和现在的成年人死亡率之间观察到了地理相关性.
- 以前的研究可能没有充分控制持续的社会经济贫困.
研究的目的:
- 调查持续的社会经济状况解释了早期生命和成人死亡率之间的观察到的联系的假设.
- 重新评估早期生活因素对成年人死亡风险的影响,考虑到当前的社会经济地位.
主要方法:
- 在英格兰和威尔士 (43个县) 的婴儿死亡率 (1895-1908年) 与因特定原因的成人死亡率 (1969-73年) 相对相关.
- 对当今社会贫困和社会阶级指数进行调整的相关性.
- 分析了65-74岁的成年人死亡率数据.
主要成果:
- 在早期婴儿死亡率和晚年成人死亡率之间发现了强烈的初始相关性.
- 这些相关性在调整为当前社会经济环境后显著减弱或消除.
- 这些发现质疑早期生活因素与成人冠心病死亡率之间的直接因果关系.
结论:
- 过去的婴儿死亡率和现在的成人死亡率之间的观察到的关联可能是由持续的社会经济贫困解释的.
- 以前的生态研究可能高估了早期生活因素对成人心血管疾病的直接影响.
- 需要进一步的纵向研究,追踪从婴儿期到成年期的个体,以澄清这些关系.
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