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针对自组装的可逆pH响应开关的合理设计

Yuri Zimenkov¹, Steven N Dublin, Rong Ni

¹Department of Chemistry and The Integrated Microscopy and Microanalytical Facility, Emory University, 1515 Dickey Drive, Atlanta, GA 30322, USA.

Journal of the American Chemical Society

|May 25, 2006

概括

TZ1H自组装成螺旋状纤维可逆,由pH控制. 这种依赖pH的组合与histidine质子化有关,使可调节的材料特性成为可能.

科学领域:

生物材料科学是生物材料的科学.
蛋白质工程是一种蛋白质工程.
超分子化学超分子化学

背景情况:

卷曲-卷曲是一种基本的蛋白质结构.
控制的自我组装是生物材料设计的关键.
响应pH的材料具有可调节的特性.

研究的目的:

为了设计一种pH响应的,可以自组装成螺旋纤维.
为了研究pH取决于自组装的机制.
为了将形状变化与质子化状态相关联.

主要方法:

的合成和表征 (TZ1H).
用于形状分析的循环二重化谱学.
传输电子显微镜用于光纤成像.
微观地质学用于机械性能评估.

主要成果:

TZ1H可以自组装成长的螺旋纤维.
组装依赖于pH值,发生在狭窄的pH值范围内.
在d位置的histidine替换对组装到imidazole的质子化.
一个线圈螺旋形状转换伴随着自组装.

结论:

工程化歇斯蒂丁残留物使得对的自我组装进行精确的pH控制.
这项研究展示了一种创建可调节的,对pH响应的生物材料的机制.
酸TZ1H为开发先进的功能性材料提供了一个平台.

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