肌肉纤维类型和习惯性打
S Smirne1, S Iannaccone, L Ferini-Strambi
1Sleep Disorders Centre, State University and Scientific Institute, Milan, Italy.
Lancet (London, England)
|March 9, 1991
概括
习惯性打是阻塞性睡眠呼吸暂停 (OSA) 的早期症状,与上呼吸道的异常肌肉纤维类型有关. 具体来说,习惯性打者表现出中缩肌肉 (MPCM) 结构的改变,这表明肌肉调失调在OSA中起着作用.
科学领域:
- 生理学 生理学 生理学
- 睡眠医学 睡眠医学
- 肌肉生物学 肌肉生物学
背景情况:
- 阻塞性睡眠呼吸暂停 (OSA) 与上呼吸道的解剖学异常有关.
- 肌肉调失调也与OSA的发病有关.
- 习惯性打被认为是OSA的初始阶段.
研究的目的:
- 为了研究与非打者相比,习惯性打者中中等喉收缩肌肉 (MPCM) 的结构特征.
- 探索潜在的基于肌肉的机制,导致习惯性打和OSA.
主要方法:
- 对13名成年男性的MPCM纤维类型 (I,IIa,IIb) 的组织学分析 (4名习惯性打者,9名不打者).
- 在打者和不打者之间比较MPCM纤维分布和直径.
- 评估肌病性或神经性变化.
主要成果:
- 非的人的MPCM显示纤维直径小于典型的四肢肌肉,I型和IIa型纤维的比例更高,IIb型纤维更少.
- 与不打者相比,习惯性打者表现出明显异常的MPCM纤维分布 (低类型I和IIb,高类型IIa) (p < 0.001).
- 习惯性打者的IIa型纤维是过度缩的,没有肌病性或神经性疾病的证据.
结论:
- 习惯性打与上呼吸道肌肉 (MPCM) 纤维类型分布和缩的特定变化有关.
- 这些发现表明肌肉调失调和运动神经元活动的适应性变化在习惯性打和OSA的发展中可能发挥作用.
- 需要进一步的研究来阐明确切的机制,将运动神经元功能与打者MPCM适应联系起来.
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