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通过L-氨酸激活淋巴细胞的自然细胞毒性
K G Park1, P D Hayes, P J Garlick
1Department of Surgery, University of Aberdeen, UK.
Lancet (London, England)
|March 16, 1991
概括
补充L-氨酸可以提高自然杀手 (NK) 和淋巴蛋白激活杀手 (LAK) 细胞的活性. 这项研究表明,氨酸增加了循环的CD56+细胞,增强了对各种疾病的免疫反应潜力.
科学领域:
- 免疫学 免疫学 免疫学
- 营养科学 营养科学
背景情况:
- 自然杀手 (NK) 和淋巴激活杀手 (LAK) 细胞对于先天性和适应性免疫是至关重要的.
- CD56+细胞是NK和LAK细胞细胞毒性的关键媒介.
- 氨酸是一种必需的氨基酸,在免疫功能中具有已知的作用.
研究的目的:
- 研究L-氨酸对NK和LAK细胞活动的体外和体内影响.
- 为了确定L-氨酸补充剂是否会影响循环中的CD56+细胞数量.
主要方法:
- 实验室试验用于评估L-氨酸对NK和LAK细胞活性的影响.
- 在体内研究涉及人体志愿者口服L-氨酸补充剂 (30g/天3天).
- 使用流细胞计和细胞毒性测试来测量CD56+细胞计数和免疫细胞活性.
主要成果:
- 在体外,L-氨酸增强了由CD56+细胞介导的NK和LAK细胞细胞毒性.
- 在体内,阿金补充剂显著增加了循环中的CD56+细胞数量 (中位数增加32%,p < 0.01).
- 这种CD56+细胞的增加与NK细胞活性 (平均91%的增加,p = 0.003) 和LAK细胞活性 (平均58%的增加,p = 0.001) 的实质性改善相关.
结论:
- 补充L-氨酸有效地增强NK和LAK细胞的活体活性.
- 研究结果表明,L-氨酸可以调节自然细胞毒性,对免疫相关疾病有潜在的治疗意义.
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