白血病的治疗反应与体外药物敏感性测定之间的相关性
1Bath Cancer Research Unit, Wolfson Centre, Royal United Hospital, UK.
Lancet (London, England)
|March 23, 1991
概括
不同染色细胞毒性 (DiSC) 试验预测了血液癌症患者的化疗反应. 较高的体外药物敏感性与更好的患者结果和存活率相关.
科学领域:
- 血液学 血液学 血液学
- 在瘤学瘤学.
- 临床药理学 临床药理学
背景情况:
- 血液性恶性瘤需要有效的治疗策略.
- 预测患者对化疗的反应对于个性化医学至关重要.
- 现有的体外试验可能无法完全捕捉临床药物敏感性.
研究的目的:
- 验证差异染色细胞毒性 (DiSC) 试验作为血液瘤治疗反应的预测工具.
- 探索DiSC试验在识别新型治疗策略和药物组合方面的实用性.
- 为了将体外药物敏感性结果与血液性恶性瘤患者的临床结果相关联.
主要方法:
- 开发和应用差异染色细胞毒性 (DiSC) 测定新鲜的人类血液瘤细胞.
- DiSC测定结果与患者对处方化疗反应的相关性.
- 在表现出对处方药物的极端体外耐药性患者中测试替代药物敏感性.
主要成果:
- 在119个DiSC测试中,有22个表明极端耐药性 (瘤细胞存活率>55%),这些患者中没有一个对化疗有反应.
- 在DiSC试验中,增加体外药物敏感性与更高比例的患者对治疗有反应相关,并改善了50%的患者存活率.
- 对处方药物极度耐药的患者在接受瘤表现出一些体外敏感性的药物治疗时,表现出更好的生存率.
结论:
- 迪斯克测定是一种有价值的预测工具,用于血液恶性瘤的化疗反应.
- DiSC测定结果可以指导有效治疗的选择,并确定可能从替代疗法中受益的患者.
- 该测试有助于发现新的治疗剂,并预测临床试验中的协同作用药物组合.
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